CAS 170727-59-0

Isoloratadine

Description:

Isoloratadine is a chemical compound that serves as an antihistamine, primarily used to alleviate allergy symptoms. It is a derivative of loratadine, which is known for its effectiveness in treating allergic rhinitis and chronic urticaria. Isoloratadine exhibits a high affinity for peripheral H1 receptors, which helps to reduce symptoms such as sneezing, runny nose, and itching without causing significant sedation, as it is less likely to cross the blood-brain barrier. The compound is characterized by its relatively long half-life, allowing for once-daily dosing in therapeutic applications. Isoloratadine is typically administered orally and is well-absorbed in the gastrointestinal tract. Its safety profile is generally favorable, with common side effects being mild and transient. As a member of the piperidine class of compounds, it possesses a specific molecular structure that contributes to its pharmacological properties. Overall, Isoloratadine represents a valuable option in the management of allergic conditions, providing relief with minimal sedative effects.

Formula: C₂₂H₂₃ClN₂O₂

InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-9,11,14,20H,2,5-6,10,12-13H2,1H3

InChI key: InChIKey=ZORGYPXITGWTSB-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)C=4CCN(C(OCC)=O)CC4)=CC1

Synonyms:

• Isoloratadine
• 1(2H)-Pyridinecarboxylic acid, 4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-3,6-dihydro-, ethyl ester

Isoloratadine (Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-3,6-dihydropyridine-1(2H)-carboxylate)

CAS: 170727-59-0

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₂H₂₃ClN₂O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 382.14481

Ref: 45-1A14360

Loratadine EP Impurity E (Isoloratadine)

CAS: 170727-59-0

Formula: C₂₂H₂₃ClN₂O₂

Color and Shape: Off-White Solid

Molecular weight: 382.89

Ref: 4Z-L-1044

Iso Loratadine

Controlled Product

CAS: 170727-59-0

Impurity Loratadine EP Impurity E
Applications Iso Loratadine (Loratadine EP Impurity E) is a Loratadine (L469575) impurity. An isomer of Loratadine used for preparation of tricyclic amides and ureas useful for inhibition of G-protein function and for treatment of proliferative diseases.
References Billah., et al.: Lipids, 26, 1172 (1991), Piwinski., et al.: J. Med. Chem., 34, 457 (1991),

Formula: C₂₂H₂₃ClN₂O₂

Color and Shape: Neat

Molecular weight: 382.88

Ref: TR-I821050

Isoloratadine

CAS: 170727-59-0

Isoloratadine, a Loratadine isomer, aids in making ureas, amides, and inhibiting G-proteins to treat proliferative diseases.

Formula: C₂₂H₂₃ClN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 382.88

Ref: TM-T20816