CAS 170729-80-3
:Aprepitant
Description:
Aprepitant is a selective antagonist of the neurokinin-1 (NK1) receptor, primarily used in the prevention of nausea and vomiting associated with chemotherapy and surgery. It is classified as a small molecule and is often administered orally. Aprepitant exhibits high affinity for the NK1 receptor, which plays a crucial role in the emetic response mediated by substance P, a neuropeptide involved in pain perception and inflammation. The substance is characterized by its relatively low solubility in water, which influences its formulation and bioavailability. Aprepitant is typically used in combination with other antiemetic agents to enhance therapeutic efficacy. Its pharmacokinetics involve extensive metabolism in the liver, primarily through the cytochrome P450 system, leading to potential drug interactions. Common side effects may include fatigue, dizziness, and gastrointestinal disturbances. Overall, Aprepitant represents a significant advancement in the management of chemotherapy-induced nausea and vomiting, improving the quality of life for patients undergoing cancer treatment.
Formula:C23H21F7N4O3
InChI:InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
InChI key:InChIKey=ATALOFNDEOCMKK-OITMNORJSA-N
SMILES:C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NNC(=O)N4
Synonyms:- 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
- 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2R-[2α(R*),3α]]-
- 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend
- 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one
- Emend
- L 754030
- Mk 869
- Mk-0869
- See more synonyms
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Found 17 products.
Aprepitant
CAS:Formula:C23H21F7N4O3Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:534.43Aprepitant
CAS:AprepitantFormula:C23H21F7N4O3Purity:99.9%Color and Shape:White. To. BeigeMolecular weight:534.15019Aprepitant
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C23H21F7N4O3Color and Shape:White Off-White PowderMolecular weight:534.435-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,3-dihydro-1H-1,2,4-triazol-3-one
CAS:Formula:C23H21F7N4O3Purity:98%Color and Shape:SolidMolecular weight:534.4267Ref: IN-DA0034H4
1g68.00€5g137.00€1kgTo inquire25g308.00€5mg26.00€250gTo inquire25mg30.00€500gTo inquire50mg31.00€250mg31.00€500mg50.00€Aprepitant
CAS:Formula:C23H21F7N4O3Purity:(HPLC) ≥ 98.0%Color and Shape:White to off-white powderMolecular weight:534.43Aprepitant Impurity 31
CAS:Formula:C27H24F7NO2Color and Shape:White To Off-White SolidMolecular weight:527.49Aprepitant
CAS:<p>Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist.</p>Formula:C23H21F7N4O3Purity:98% - 99.68%Color and Shape:Off-White To Light Yellow Cyrstalline SolidMolecular weight:534.43Aprepitant
CAS:Controlled Product<p>Applications Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).<br>References (1) Takemoto, H., et al.: nt J Clin Oncol (2016) (2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016) (3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)<br></p>Formula:C23H21F7N4O3Color and Shape:Off-WhiteMolecular weight:534.43Aprepitant
CAS:<p>Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.</p>Formula:C23H21F7N4O3Purity:Min. 98%Color and Shape:White Off-White PowderMolecular weight:534.43 g/molAprepitant - Bio-X ™
CAS:<p>Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.</p>Formula:C23H21F7N4O3Purity:Min. 98 Area-%Molecular weight:534.43 g/mol
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