CAS 170729-80-3

Aprepitant

Description:

Aprepitant is a selective antagonist of the neurokinin-1 (NK1) receptor, primarily used in the prevention of nausea and vomiting associated with chemotherapy and surgery. It is classified as a small molecule and is often administered orally. Aprepitant exhibits high affinity for the NK1 receptor, which plays a crucial role in the emetic response mediated by substance P, a neuropeptide involved in pain perception and inflammation. The substance is characterized by its relatively low solubility in water, which influences its formulation and bioavailability. Aprepitant is typically used in combination with other antiemetic agents to enhance therapeutic efficacy. Its pharmacokinetics involve extensive metabolism in the liver, primarily through the cytochrome P450 system, leading to potential drug interactions. Common side effects may include fatigue, dizziness, and gastrointestinal disturbances. Overall, Aprepitant represents a significant advancement in the management of chemotherapy-induced nausea and vomiting, improving the quality of life for patients undergoing cancer treatment.

Formula: C₂₃H₂₁F₇N₄O₃

InChI: InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1

InChI key: InChIKey=ATALOFNDEOCMKK-OITMNORJSA-N

SMILES: C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NNC(=O)N4

Synonyms:

• 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
• 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2R-[2α(R*),3α]]-
• 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend
• 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one
• Emend
• L 754030
• Mk 869
• Mk-0869

Aprepitant

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 534.43

Ref: 3B-A3135

Aprepitant impurity standard

CAS: 170729-80-3

Aprepitant impurity standard

Color and Shape: Off White Solid

Ref: 47-1148

APREPITANT CRS

CAS: 170729-80-3

APREPITANT CRS

Formula: C₂₃H₂₁F₇N₄O₃

Molecular weight: 534.4267

Ref: 41-Y0001825

Aprepitant

CAS: 170729-80-3

Aprepitant

Formula: C₂₃H₂₁F₇N₄O₃

Purity: 99.9%

Color and Shape: White. To. Beige

Molecular weight: 534.15019

Ref: 47-1138

Aprepitant

CAS: 170729-80-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₃H₂₁F₇N₄O₃

Color and Shape: White Off-White Powder

Molecular weight: 534.15019

Ref: 45-1041904

5-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,3-dihydro-1H-1,2,4-triazol-3-one

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 534.4267

Ref: IN-DA0034H4

Aprepitant

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 534.43

Ref: 4Z-A-321

Aprepitant

CAS: 170729-80-3

Aprepitant

Purity: 99%

Molecular weight: 534.43g/mol

Ref: 54-PC109217

Aprepitant

CAS: 170729-80-3

Aprepitant

Purity: ≥98%

Molecular weight: 534.43g/mol

Ref: 54-BUP15404

Aprepitant

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 534.43

Ref: 7W-GP4641

Aprepitant Impurity 31

CAS: 170729-80-3

Formula: C₂₇H₂₄F₇NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 527.49

Ref: 4Z-A-3212

Aprepitant

Controlled Product

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Color and Shape: Neat

Molecular weight: 534.43

Ref: 86-MM3251.00

Aprepitant

CAS: 170729-80-3

Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist.

Formula: C₂₃H₂₁F₇N₄O₃

Purity: 98% - 99.68%

Color and Shape: Off-White To Light Yellow Cyrstalline Solid

Molecular weight: 534.43

Ref: TM-T1743

Aprepitant

Controlled Product

CAS: 170729-80-3

Applications Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).
References (1) Takemoto, H., et al.: nt J Clin Oncol (2016) (2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016) (3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)

Formula: C₂₃H₂₁F₇N₄O₃

Color and Shape: Off-White

Molecular weight: 534.43

Ref: TR-A729800

Aprepitant

CAS: 170729-80-3

Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.

Formula: C₂₃H₂₁F₇N₄O₃

Purity: Min. 98%

Color and Shape: White Off-White Powder

Molecular weight: 534.43 g/mol

Ref: 3D-FA17962

Aprepitant - Bio-X ™

CAS: 170729-80-3

Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.

Formula: C₂₃H₂₁F₇N₄O₃

Purity: Min. 98 Area-%

Molecular weight: 534.43 g/mol

Ref: 3D-BA164216

Fosaprepitant Dimeglumine Impurity C

CAS: 170729-80-3

Formula: C₂₃H₂₁F₇N₄O₃

Molecular weight: 534.43

Ref: ST-EA-CP-F36003