CAS 170784-58-4

5'-Guanylic acid, 2'-deoxy-2'-fluoro-

Description:

5'-Guanylic acid, 2'-deoxy-2'-fluoro- is a modified nucleotide that features a guanine base, a ribose sugar, and a phosphate group, with a notable substitution of a fluorine atom at the 2' position of the sugar. This modification can influence the compound's biochemical properties, such as its stability and interaction with enzymes, making it of interest in various fields, including medicinal chemistry and molecular biology. The presence of the fluorine atom may enhance resistance to nucleases, thereby increasing the compound's potential as a therapeutic agent or in the development of oligonucleotide-based drugs. Additionally, this compound can participate in various biochemical pathways, including those related to RNA synthesis and signaling. Its unique structure allows for potential applications in research and drug development, particularly in targeting specific biological processes or pathways. Overall, 5'-Guanylic acid, 2'-deoxy-2'-fluoro- exemplifies the importance of chemical modifications in enhancing the functionality and efficacy of nucleotides in biological systems.

Formula: C₁₀H₁₃FN₅O₇P

2'-Deoxy-2'-fluoroguanosine-5'-monophosphate

CAS: 170784-58-4

2'-Deoxy-2'-fluoroguanosine-5'-monophosphate is a phosphoramidite monoester with a diphosphate group that has been synthetically modified to provide antiviral and anticancer activity. It is an activator of DNA synthesis and inhibits the proliferation of tumor cells by interfering with DNA replication. The compound is also used as a precursor for the synthesis of 2'-deoxy-2'-fluoroguanosine, which has potent anti-HIV activity.

Formula: C₁₀H₁₃FN₅O₇P

Purity: Min. 95%

Molecular weight: 365.21 g/mol

Ref: 3D-ND145454