CAS 1708118-13-1

Everolimus Ring-Opening Impurity

Description:

Everolimus Ring-Opening Impurity, identified by the CAS number 1708118-13-1, is a chemical compound associated with the pharmaceutical agent everolimus, which is an mTOR inhibitor used primarily in cancer therapy and organ transplantation. This impurity arises during the synthesis or degradation of everolimus and is characterized by its specific molecular structure, which typically includes a modified ring system compared to the parent compound. The presence of such impurities is significant in pharmaceutical formulations, as they can affect the efficacy and safety of the drug. The compound may exhibit distinct physical and chemical properties, such as solubility, stability, and reactivity, which are critical for quality control and regulatory compliance in drug manufacturing. Analytical techniques like HPLC and mass spectrometry are often employed to identify and quantify this impurity in pharmaceutical products. Understanding the characteristics of this impurity is essential for ensuring the overall quality and safety of everolimus-containing medications.

Formula: C₅₃H₈₃NO₁₄

Synonyms:

• Everolimus Impurity 012-99
• (S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)
• Everolimus Impurity 33
• (S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-Hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl 1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
• EverolimusRetroaldolDegradationProduct
• (2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl (S)-1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
• Everolimus Open-Ring Impurity
• Everolimus Open-Ring Aldehyde Impurity
• Everolimus Impurity 2（012-99）

Everolimus Ring-Opening Impurity (Mixture of Isomers)

CAS: 1708118-13-1

Formula: C₅₃H₈₃NO₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 958.25

Ref: 4Z-E-104

Everolimus Retroaldol Degradation Product

Controlled Product

CAS: 1708118-13-1

Impurity Everolimus Impurity
Stability Light and temperature Sensitive
Applications Everolimus Retroaldol Degradation Product is an impurity of Everolimus (E945400). Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Everolimus Impurity D
References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),

Formula: C₅₃H₈₃NO₁₄

Color and Shape: Neat

Molecular weight: 958.22

Ref: TR-E945420

Everolimus retroaldol degradation product

CAS: 1708118-13-1

Everolimus is a drug that is used in the treatment of certain cancers. It acts by binding to the cytosolic protein receptor known as the mammalian target of rapamycin (mTOR). This binding causes the inhibition of mTOR. Everolimus is converted by enzymes into a number of metabolites, including the retroaldol degradation product. The retroaldol degradation product has been shown to bind to ion channels and inhibit their activity. It is also a ligand for several receptors, such as the peptide growth hormone releasing factor (GHRF) receptor.

Formula: C₅₃H₈₃NO₁₄

Purity: Min. 95%

Molecular weight: 958.2 g/mol

Ref: 3D-ITC11813

Everolimus Ring-opening Impurity

CAS: 1708118-13-1

Formula: C₅₃H₈₃NO₁₄

Molecular weight: 958.2

Ref: ST-EA-CP-E33008