CAS 170912-52-4

Donitriptan

Description:

Donitriptan is a chemical compound classified as a triptan, which is primarily used in the treatment of migraine headaches. It functions as a selective agonist for serotonin receptors, particularly the 5-HT_1B and 5-HT_1D subtypes, which play a crucial role in vasoconstriction and the modulation of neurotransmitter release. This mechanism helps alleviate migraine symptoms by reducing inflammation and constricting dilated blood vessels in the brain. Donitriptan is characterized by its relatively high potency and specificity for these serotonin receptors, which contributes to its effectiveness in migraine management. The compound is typically administered in a form that allows for rapid absorption and onset of action, making it suitable for acute migraine treatment. As with other triptans, potential side effects may include dizziness, fatigue, and sensations of tingling or warmth. Overall, Donitriptan represents a targeted approach to migraine relief, leveraging its pharmacological properties to address the underlying mechanisms of the condition.

Formula: C₂₃H₂₅N₅O₂

InChI: InChI=1S/C23H25N5O2/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19/h1-6,13,15,26H,7-12,16,24H2

InChI key: InChIKey=SOHCKWZVTCTQBG-UHFFFAOYSA-N

SMILES: C(CN)C=1C=2C(NC1)=CC=C(OCC(=O)N3CCN(CC3)C4=CC=C(C#N)C=C4)C2

Synonyms:

• 1-(((3-(2-Aminoethyl)indol-5-yl)oxy)acetyl)-4-(p-cyanophenyl)piperazine.
• 4-[4-[2-[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]benzonitrile
• Benzonitrile, 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]-
• Donitriptan
• Piperazine, 1-[[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-

Donitriptan

Controlled Product

CAS: 170912-52-4

Donitriptan is a 5-HT agonist that is used to treat migraine. It is an analog of sumatriptan, which has been shown to be effective for the relief of migraine symptoms. Donitriptan has been shown to have haemodynamic effects, such as a decrease in blood pressure and heart rate. This drug also has antimigraine properties, which are thought to be due to its ability to increase the production of acetylcholine in the brain. The maximal response of donitriptan occurs at a high concentration and it has been shown to be effective against both vascular and non-vascular causes of migraines.

Formula: C₂₃H₂₅N₅O₂

Purity: Min. 95%

Molecular weight: 403.5 g/mol

Ref: 3D-VGA91252

Donitriptan

CAS: 170912-52-4

Donitriptan 是一种 5-HT 受体激动剂，对 5-HT1B 和 5-HT1D 的 pKi 分别为 9.4 和 9.3。

Formula: C₂₃H₂₅N₅O₂

Purity: 98.76%

Color and Shape: Solid

Molecular weight: 403.48

Ref: TM-T11075