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CAS 171049-14-2

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Lotrafiban

Description:
Lotrafiban is a chemical compound classified as a potent and selective antagonist of the glycoprotein IIb/IIIa receptor, which plays a crucial role in platelet aggregation. It is primarily investigated for its potential use in preventing thrombotic events, particularly in patients with cardiovascular diseases. The substance is characterized by its ability to inhibit platelet activation and aggregation, thereby reducing the risk of clot formation. Lotrafiban is typically administered in a clinical setting and has been studied for its efficacy in various cardiovascular conditions, including acute coronary syndromes. Its pharmacokinetic properties include a relatively short half-life, necessitating careful dosing regimens to maintain therapeutic levels. Additionally, Lotrafiban's safety profile has been evaluated in clinical trials, highlighting potential side effects such as bleeding complications, which are common with antiplatelet therapies. Overall, Lotrafiban represents a significant area of research in the development of antithrombotic agents aimed at improving patient outcomes in cardiovascular health.
Formula:C23H32N4O4
InChI:InChI=1S/C23H32N4O4/c1-26-14-18-12-17(2-3-19(18)25-20(23(26)31)13-21(28)29)22(30)27-10-6-16(7-11-27)15-4-8-24-9-5-15/h2-3,12,15-16,20,24-25H,4-11,13-14H2,1H3,(H,28,29)/t20-/m0/s1
InChI key:InChIKey=PYZOVVQJTLOHDG-FQEVSTJZSA-N
SMILES:C(=O)(C=1C=C2C(N[C@@H](CC(O)=O)C(=O)N(C)C2)=CC1)N3CCC(CC3)C4CCNCC4
Synonyms:
  • SB 214857
  • Lotrafiban
  • 1H-1,4-Benzodiazepine-2-acetic acid, 7-([4,4′-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-, (2S)-
  • (2S)-7-([4,4′-Bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid
  • 1H-1,4-Benzodiazepine-2-acetic acid, 7-([4,4′-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-, (S)-
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