4,6-Dichloropyrido[3,4-d]pyrimidine is a heterocyclic compound characterized by its fused pyridine and pyrimidine rings, which contain two chlorine substituents at the 4 and 6 positions. This compound typically exhibits a crystalline solid form and is known for its potential applications in medicinal chemistry, particularly as a scaffold for developing pharmaceuticals. Its structure contributes to its biological activity, often influencing its interaction with various biological targets. The presence of chlorine atoms enhances its lipophilicity and may affect its solubility and reactivity. Additionally, 4,6-dichloropyrido[3,4-d]pyrimidine may exhibit properties such as moderate stability under standard conditions, but it should be handled with care due to potential toxicity. As with many heterocycles, it may participate in various chemical reactions, including nucleophilic substitutions and cycloadditions, making it a versatile compound in synthetic organic chemistry. Overall, its unique structure and properties make it a subject of interest in both research and industrial applications.

4,6-DICHLOROPYRIDO[3,4-D]PYRIMIDINE

171178-48-6: 4,6-Dichloropyrido[3,4-d]pyrimidine is a heterocyclic compound characterized by its fused pyridine and pyrimidine rings, which contain two chlorine substituents at the 4 and 6 positions. This compound typically exhibits a crystalline solid form and is known for its potential applications in medicinal chemistry, particularly as a scaffold for developing pharmaceuticals. Its structure contributes to its biological activity, often influencing its interaction with various biological targets. The presence of chlorine atoms enhances its lipophilicity and may affect its solubility and reactivity. Additionally, 4,6-dichloropyrido[3,4-d]pyrimidine may exhibit properties such as moderate stability under standard conditions, but it should be handled with care due to potential toxicity. As with many heterocycles, it may participate in various chemical reactions, including nucleophilic substitutions and cycloadditions, making it a versatile compound in synthetic organic chemistry. Overall, its unique structure and properties make it a subject of interest in both research and industrial applications.

<p>4,6-Dichloropyrido[3,4-d]pyrimidine is a potent and selective inhibitor of the tyrosine kinase Egfr. It has been shown to inhibit growth in xenograft mouse models. 4,6-Dichloropyrido[3,4-d]pyrimidine has been shown to have anticancer effects by inhibiting the proliferation of cancer cells. This drug also induces apoptosis in cancer cells through inhibition of the Egfr kinase. 4,6-Dichloropyrido[3,4-d]pyrimidine is an anticancer agent that inhibits cell growth and induces apoptosis in cancer cells with a potency similar to that of EGFR inhibitors such as erlotinib.</p>

CAS 171178-48-6

4,6-DICHLOROPYRIDO[3,4-D]PYRIMIDINE

4,6-dichloropyrido[3,4-d]pyrimidine

Ref: 3D-WGA17848