CAS 171235-71-5

TAPI-1

Description:

TAPI-1, with the CAS number 171235-71-5, is a chemical compound known as a selective inhibitor of matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9. These enzymes play crucial roles in the degradation of extracellular matrix components, which is significant in various physiological and pathological processes, including tissue remodeling, wound healing, and cancer metastasis. TAPI-1 is characterized by its ability to inhibit the activity of these enzymes, making it a valuable tool in research related to cancer biology and tissue repair. The compound is typically used in laboratory settings to study the effects of MMP inhibition on cellular processes and to explore potential therapeutic applications. Its structure includes specific functional groups that contribute to its inhibitory activity, and it is often utilized in biochemical assays to evaluate MMP activity in various biological samples. As with many chemical inhibitors, the specificity and potency of TAPI-1 can vary depending on the experimental conditions and the biological context in which it is applied.

L-Alaninamide,N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-

CAS: 171235-71-5

Formula: C₂₆H₃₇N₅O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 499.6025

Ref: IN-DA00AQC4

(S,S)-TAPI-1

CAS: 171235-71-5

"(S,S)-TAPI-1, an isomer of TAPI-1, inhibits MMPs and TACE (ADAM17), reducing cell surface protein shedding."

Formula: C₂₆H₃₇N₅O₅

Color and Shape: Solid

Molecular weight: 499.6

Ref: TM-T63390

TAPI-1 Trifluoroacetic Acid Salt

Controlled Product

CAS: 171235-71-5

Applications TAPI-1 Trifluoroacetic Acid Salt is a TNF-α converting enzyme (TACE) inhibitor, which blocks shedding of cytokine receptors. It is a modulation of juxtamembrane cleavage (shedding) of angiotensin-converting enzyme by stalking glycosylation in relation to an alternative shedding protease.
References Schwager, S.L.U, et al.: Biochemistry, 38, 10388 (1999); Mullberg, J., et al.: J. Immunol., 155, 5198 (1995); Slack, B.E., et al.: Biochem. J., 357, 787 (2001);

Formula: C₂₆H₃₇N₅O₅•x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 499.60 + x(114.02)

Ref: TR-T007310

TAPI-1

CAS: 171235-71-5

TAPI-1 is an inhibitor of TACE (TNF-α converting enzyme, also known as ADAM17) and matrix metalloproteinases (MMPs). It blocks the shedding of several cell surface proteins, including tumor necrosis factor-alpha (TNF-α), IL-6 receptor, and TNF receptors p60 (TNFRI) and p80 (TNFRII).

Formula: C₂₆H₃₇N₅O₅

Purity: Min. 95%

Molecular weight: 499.6 g/mol

Ref: 3D-WGA23571