CAS 171335-80-1: Exatecan

Description: Exatecan is a synthetic chemical compound classified as a topoisomerase I inhibitor, primarily developed for its potential use in cancer therapy. It belongs to the class of camptothecin derivatives, which are known for their ability to interfere with DNA replication and transcription by stabilizing the DNA-topoisomerase I complex. This action ultimately leads to the induction of apoptosis in rapidly dividing cancer cells. Exatecan exhibits a relatively high potency against various tumor types, including solid tumors. Its chemical structure features a lactone ring, which is crucial for its biological activity. The compound is typically administered intravenously and has undergone various clinical trials to assess its efficacy and safety profile. Like many anticancer agents, Exatecan may present side effects, including myelosuppression, gastrointestinal disturbances, and potential cardiotoxicity. Ongoing research continues to explore its therapeutic potential, optimal dosing regimens, and combination strategies with other anticancer agents to enhance its effectiveness while minimizing adverse effects.

Formula: C₂₄H₂₂FN₃O₄

InChI: InChI=1S/C24H22FN3O4/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19/h6-7,16,31H,3-5,8-9,26H2,1-2H3/t16-,24-/m0/s1

InChI key: InChIKey=ZVYVPGLRVWUPMP-FYSMJZIKSA-N

SMILES: O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=C(F)C(=C6C5=C(C4C3)C(N)CC6)C

Synonyms:

• (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione
• (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione
• (1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione
• (1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-1-amine
• 10H,13H-Benzo[De]Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-10,13-Dione, 1-Amino-9-Ethyl-5-Fluoro-1,2,3,9,12,15-Hexahydro-9-Hydroxy-4-Methyl-, (1S,9S)-, Monomethanesulfonate (Salt)
• 10H,13H-Benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9S)-
• 10H,13H-Benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-
• Dx 8951
• Exatecan Alideximer
• Exatecan

Exatecan

CAS: 171335-80-1

• Formula: C₂₄H₂₂FN₃O₄
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 435.4476

Exatecan

CAS: 171335-80-1

• Purity: 99.83%
• Molecular weight: 435.45g/mol

Exatecan

CAS: 171335-80-1

Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 …

• Formula: C₂₄H₂₂FN₃O₄
• Purity: 99.64% - 99.84%
• Color and Shape: Solid
• Molecular weight: 435.45

Exatecan-d3

CAS: 171335-80-1

• Formula: C₂₄H₁₉D₃FN₃O₄
• Molecular weight: 438.47

Exatecan Mesylate

CAS: 169869-90-3 171335-80-1

• Formula: C₂₄H₂₂FN₃O₄·CH₄O₃S
• Molecular weight: 435.46 96.11

Exatecan-d3

CAS: 171335-80-1

• Formula: C₂₄H₁₉D₃FN₃O₄
• Molecular weight: 438.47

Exatecan

CAS: 171335-80-1

Exatecan is a disulfide bond-containing peptide that has potent antitumor activity. It is an exatecan …

• Formula: C₂₄H₂₂FN₃O₄
• Purity: Min. 95%
• Molecular weight: 435.45 g/mol