CAS 171335-80-1

Exatecan

Description:

Exatecan is a synthetic chemical compound classified as a topoisomerase I inhibitor, primarily developed for its potential use in cancer therapy. It belongs to the class of camptothecin derivatives, which are known for their ability to interfere with DNA replication and transcription by stabilizing the DNA-topoisomerase I complex. This action ultimately leads to the induction of apoptosis in rapidly dividing cancer cells. Exatecan exhibits a relatively high potency against various tumor types, including solid tumors. Its chemical structure features a lactone ring, which is crucial for its biological activity. The compound is typically administered intravenously and has undergone various clinical trials to assess its efficacy and safety profile. Like many anticancer agents, Exatecan may present side effects, including myelosuppression, gastrointestinal disturbances, and potential cardiotoxicity. Ongoing research continues to explore its therapeutic potential, optimal dosing regimens, and combination strategies with other anticancer agents to enhance its effectiveness while minimizing adverse effects.

Formula: C₂₄H₂₂FN₃O₄

InChI: InChI=1S/C24H22FN3O4/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19/h6-7,16,31H,3-5,8-9,26H2,1-2H3/t16-,24-/m0/s1

InChI key: InChIKey=ZVYVPGLRVWUPMP-FYSMJZIKSA-N

SMILES: N[C@@H]1C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=C(CC1)C(C)=C(F)C6

Synonyms:

• (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione
• (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione
• (1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione
• (1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-1-amine
• 10H,13H-Benzo[De]Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-10,13-Dione, 1-Amino-9-Ethyl-5-Fluoro-1,2,3,9,12,15-Hexahydro-9-Hydroxy-4-Methyl-, (1S,9S)-, Monomethanesulfonate (Salt)
• 10H,13H-Benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9S)-
• 10H,13H-Benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-
• Dx 8951
• Exatecan Alideximer
• Exatecan

Exatecan

CAS: 171335-80-1

Formula: C₂₄H₂₂FN₃O₄

Molecular weight: 435.46

Ref: ST-EA-CP-E121000

Exatecan

CAS: 171335-80-1

Formula: C₂₄H₂₂FN₃O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 435.4476

Ref: IN-DA00ABK3

Exatecan

CAS: 171335-80-1

Exatecan

Purity: ≥98%

Molecular weight: 435.45g/mol

Ref: 54-BUP11396

Exatecan-d3

CAS: 171335-80-1

Formula: C₂₄H₁₉D₃FN₃O₄

Molecular weight: 438.47

Ref: 4Z-E-244002

Exatecan

CAS: 171335-80-1

Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used in

Formula: C₂₄H₂₂FN₃O₄

Purity: 99.69% - 99.91%

Color and Shape: Solid

Molecular weight: 435.45

Ref: TM-T11249