CAS 171436-38-7

H-SER-LEU-ILE-GLY-ARG-LEU-NH2

Description:

The chemical substance identified as H-SER-LEU-ILE-GLY-ARG-LEU-NH2, with the CAS number 171436-38-7, is a peptide composed of a specific sequence of amino acids: serine (Ser), leucine (Leu), isoleucine (Ile), glycine (Gly), arginine (Arg), and another leucine (Leu). This peptide features an N-terminal modification (indicated by "H-") and a C-terminal amide group (indicated by "NH2"), which can influence its stability and biological activity. Peptides like this one are often studied for their roles in biological processes, including signaling, enzyme activity, and as potential therapeutic agents. The presence of both hydrophobic (Leu, Ile) and polar (Ser, Gly) amino acids suggests that the peptide may have diverse interactions in biological systems. Additionally, the arginine residue can contribute to positive charge and potential binding interactions with negatively charged molecules. Overall, this peptide's characteristics make it a subject of interest in biochemistry and pharmacology.

Formula: C₂₉H₅₆N₁₀O₇

Synonyms:

• Ser-Leu-Ile-Gly-Arg-Leu-Amide
• Sligrlamide
• Sligrl-Nh2
• Thrombin Receptor-Like 1 (1-6) Amide (Mouse, Rat)
• Proteinase Activated Receptor 2 (1-6) Amide (Mouse, Rat)
• Proline/Betaine Transporter Fragment Amide
• Par-2 (1-6) Amide (Mouse, Rat)
• Par2-Ap

PAR-2 (1-6) amide (mouse, rat)

CAS: 171436-38-7

SLIGRL-amide, protease-activated receptor-2 (PAR2) selective agonist. The reverted PAR2 peptide can be used as inactive control.

Formula: C₂₉H₅₆N₁₀O₇

Purity: 99.4%

Color and Shape: White

Molecular weight: 656.83

Ref: 01-4033483

SLIGRL-NH2

CAS: 171436-38-7

SLIGRL-NH2

Purity: ≥98%

Molecular weight: 656.82g/mol

Ref: 54-BUP21798

SLIGRL-NH2

CAS: 171436-38-7

SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.

Formula: C₂₉H₅₆N₁₀O₇

Purity: 98.29%

Color and Shape: Solid

Molecular weight: 656.82

Ref: TM-TP1046

PAR-2 (1-6) (mouse, rat)

CAS: 171436-38-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₂₉H₅₆N₁₀O₇

Molecular weight: 656.83 g/mol

Ref: 3D-PP50110

H-Ser-Leu-Ile-Gly-Arg-Leu-NH2

CAS: 171436-38-7

H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 is a cyclase inhibitor that binds to the neurokinin 1 receptor, leading to an inhibition of the release of inflammatory substances in the bowel. HSLIGRL can also inhibit epidermal growth factor (EGF), which suppresses inflammation and cell proliferation. HSLIGRL also inhibits inflammatory bowel disease by decreasing the production of prostaglandins, which are chemical messengers involved in pain and inflammation. HSLIGRL has been shown to be effective against low potency benzalkonium chloride, which is often used as a preservative in pharmaceuticals. This compound has been shown to reduce inflammation by inhibiting proinflammatory cytokines such as TNFα and IL1β.

Formula: C₂₉H₅₆N₁₀O₇

Purity: Min. 95%

Molecular weight: 656.83 g/mol

Ref: 3D-PAR-3664-PI

PAR-2 (1-6) amide (mouse, rat)

CAS: 171436-38-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₂₉H₅₆N₁₀O₇

Molecular weight: 656.83 g/mol

Ref: 3D-PP50028

SLIGRL-NH2

CAS: 171436-38-7

Formula: C₂₉H₅₆N₁₀O₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 656.83

Ref: 10-F047237

SL-NH2 Trifluoroacetic Acid Salt (1:2)

Controlled Product

CAS: 171436-38-7

Applications SL-NH2 Trifluoroacetic Acid Salt (1:2), is a PAR2 acute agonist which causes hyperglasia, or an increase to the sensitivity to pain.
References Huang, Z. et al.; Brain Res., 1425, 20 (2011);

Formula: C₂₉H₅₆N₁₀O₇•2(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 656.82211402

Ref: TR-S560005

PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt

CAS: 171436-38-7

PAR-2 agonist is a synthetic peptide that activates PAR-2. It binds to PAR-2 receptors, which are present in the mesenteric vasculature and in various other tissues. Activation of PAR-2 leads to an increase in intracellular calcium concentration, activation of protein kinase C, cytosolic calcium ion release, phosphorylation of myosin light chain, muscle cell proliferation, transcription and translation initiation, and increased production of vasoactive intestinal peptide. This drug also has anti-inflammatory effects and stimulates epidermal growth factor (EGF) and thrombin receptor expression as well as growth factor production.

Formula: C₂₉H₅₆N₁₀O₇

Purity: Min. 95%

Molecular weight: 656.82 g/mol

Ref: 3D-FP109453