CAS 171596-29-5

Tadalafil

Description:

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor primarily used for the treatment of erectile dysfunction and pulmonary arterial hypertension. It is characterized by its ability to enhance blood flow by relaxing the blood vessels in the penis, facilitating an erection in response to sexual stimulation. Tadalafil has a long half-life, allowing for extended effects, which can last up to 36 hours, earning it the nickname "the weekend pill." The chemical structure of tadalafil includes a bicyclic structure with a pyrimidine ring, contributing to its pharmacological properties. It is typically administered orally and is available in various dosages. Tadalafil is generally well-tolerated, but it can cause side effects such as headaches, flushing, and dyspepsia. It is important to note that tadalafil should not be used in conjunction with nitrates due to the risk of severe hypotension. Overall, tadalafil represents a significant advancement in the management of erectile dysfunction and related conditions, providing patients with a reliable therapeutic option.

Formula: C₂₂H₁₉N₃O₄

InChI: InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1

InChI key: InChIKey=WOXKDUGGOYFFRN-IIBYNOLFSA-N

SMILES: O=C1N2[C@@H](C3=C(C=4C(N3)=CC=CC4)C[C@@]2(C(=O)N(C)C1)[H])C=5C=C6C(=CC5)OCO6

Synonyms:

• (6R,12Ar)-6-(1,3-Benzodioxol-5-Yl)-2,3,6,7,12,12A-Hexahydro-2-Methyl-Pyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione
• (6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
• (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
• (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
• (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-3,4,6,6a,7,11b,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-1(2H)-one
• Adcirca
• Cialis
• Gf 196960
• Ic-351
• Icos 351
• Lifta
• Pentadafil
• Pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-
• Pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R-trans)-
• Tadalafil Lilly
• Tadanafil
• Tadfil
• Tadora
• Talmanco
• Tardenafil
• Tildenafil
• Uk 336017

Tadalafil

CAS: 171596-29-5

Formula: C₂₂H₁₉N₃O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 389.41

Ref: 3B-T4029

Tadalafil 1.0 mg/ml in Acetonitrile

CAS: 171596-29-5

Color and Shape: Single Solution

Ref: 61-AMP0806.00-11

TADALAFIL CRS

CAS: 171596-29-5

TADALAFIL CRS

Formula: C₂₂H₁₉N₃O₄

Molecular weight: 389.404

Ref: 41-Y0001417

Tadalafil

CAS: 171596-29-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₂H₁₉N₃O₄

Color and Shape: White Off-White Powder

Molecular weight: 389.13756

Ref: 45-1642879

(6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione

CAS: 171596-29-5

Formula: C₂₂H₁₉N₃O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 389.4040

Ref: IN-DA0037XA

Tadalafil

CAS: 171596-29-5

Tadalafil (IC-351) is a carboline-based compound with vasodilatory activity.

Formula: C₂₂H₁₉N₃O₄

Purity: 97.03%

Color and Shape: Off-White Cyrstalline Solid

Molecular weight: 389.40

Ref: TM-T1398

Cialis

CAS: 171596-29-5

Cialis

Purity: 99%

Molecular weight: 389.4g/mol

Ref: 54-OR1026996

Tadalafil

CAS: 171596-29-5

Formula: C₂₂H₁₉N₃O₄

Purity: ≥ 98%

Color and Shape: White to light-yellow powder

Molecular weight: 389.40

Ref: 7W-GP0380

Tadalafil

CAS: 171596-29-5

Formula: C₂₂H₁₉N₃O₄

Color and Shape: White To Off-White Solid

Molecular weight: 389.41

Ref: 4Z-T-103

Tadalafil

CAS: 171596-29-5

Tadalafil

Purity: ≥95%

Molecular weight: 389.4g/mol

Ref: 54-BUP17162

Tadalafil

CAS: 171596-29-5

Color and Shape: Neat

Ref: 61-FOR0806.00

Tadalafil

CAS: 171596-29-5

Formula: C₂₂H₁₉N₃O₄

Color and Shape: Neat

Molecular weight: 389.40

Ref: 04-C17133000

Tadalafil

CAS: 171596-29-5

Color and Shape: Neat

Ref: 86-MM0806.00

Tadalafil

Controlled Product

CAS: 171596-29-5

Stability Unstable in Methanol
Applications Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.
References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003); Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005); Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005);

Formula: C₂₂H₁₉N₃O₄

Color and Shape: White To Off-White

Molecular weight: 389.40

Ref: TR-T004500

Tadalafil

CAS: 171596-29-5

Tadalafil is a phosphodiesterase type 5 inhibitor that is used to treat erectile dysfunction by increasing blood flow to the penis. It is an oral drug that blocks the enzyme phosphodiesterase type 5 (PDE5) and increases the levels of cyclic guanosine monophosphate (cGMP) in smooth muscle cells, leading to vasodilation and increased blood flow. Tadalafil has been shown to be effective in men with pulmonary hypertension and primary pulmonary hypertension. Tadalafil also has a side-effect profile similar to other PDE5 inhibitors, including headache, dizziness, nausea, nasal congestion or runny nose, indigestion, diarrhea or constipation, back pain and muscle pain. This drug also interacts with drugs that can cause serious adverse effects if taken with PDE5 inhibitors. Tadalafil is not active against bacteria; therefore it cannot be used for the treatment of bacterial infections such as tuberculosis.

Formula: C₂₂H₁₉N₃O₄

Purity: (Hplc) Min. 98%

Color and Shape: White Powder

Molecular weight: 389.4 g/mol

Ref: 3D-FB02802

Tadalafil - Bio-X ™

CAS: 171596-29-5

Tadalafil is a phosphodiesterase (PDE) inhibitor used to treat erectile dysfunction. It works by inhibiting the enzyme PDE, which is responsible for breaking down cGMP, a molecule that relaxes smooth muscle cells in the penis and allows for increased blood flow. Tadalafil has an ability to also act as a channel inhibitor and nerve growth factor inhibitor. Additionally, it is said to aid with pulmonary arterial hypertension by relaxing the blood vessels in the lungs to allow blood to flow more easily.

Formula: C₂₂H₁₉N₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 389.4 g/mol

Ref: 3D-BT164435

Tadalafil-13C2,d3

Controlled Product

CAS: 171596-29-5

Applications Tadalafil-13C2,d3 is labelled Tadalafil (T004500) which is used for the treatment of erectile dysfunction. It is a phosphodiesterase 5 inhibitor.
References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)

Formula: C₂₀₁₃C₂H₁₆D₃N₃O₄

Color and Shape: White Powder

Molecular weight: 394.41

Ref: TR-T004502

2-Triethylmethyl Tadalafil

Controlled Product

CAS: 171596-29-5

Formula: C₂₇H₂₉N₃O₄

Color and Shape: Neat

Molecular weight: 459.537

Ref: TR-T776663