CAS 171596-29-5: Tadalafil
Description:Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor primarily used for the treatment of erectile dysfunction and pulmonary arterial hypertension. It is characterized by its ability to enhance blood flow by relaxing the blood vessels in the penis, facilitating an erection in response to sexual stimulation. Tadalafil has a long half-life, allowing for extended effects, which can last up to 36 hours, earning it the nickname "the weekend pill." The chemical structure of tadalafil includes a bicyclic structure with a pyrimidine ring, contributing to its pharmacological properties. It is typically administered orally and is available in various dosages. Tadalafil is generally well-tolerated, but it can cause side effects such as headaches, flushing, and dyspepsia. It is important to note that tadalafil should not be used in conjunction with nitrates due to the risk of severe hypotension. Overall, tadalafil represents a significant advancement in the management of erectile dysfunction and related conditions, providing patients with a reliable therapeutic option.
Formula:C22H19N3O4
InChI:InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
InChI key:InChIKey=WOXKDUGGOYFFRN-IIBYNOLFSA-N
SMILES:O=C1N2C(C3=CC=C4OCOC4=C3)C=5NC=6C=CC=CC6C5CC2C(=O)N(C)C1
- Synonyms:
- (6R,12Ar)-6-(1,3-Benzodioxol-5-Yl)-2,3,6,7,12,12A-Hexahydro-2-Methyl-Pyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione
- (6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
- (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
- (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
- (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-3,4,6,6a,7,11b,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-1(2H)-one
- Adcirca
- Cialis
- Gf 196960
- Ic-351
- Icos 351
- See more synonyms
- Lifta
- Pentadafil
- Pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-
- Pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R-trans)-
- Tadalafil Lilly
- Tadanafil
- Tadfil
- Tadora
- Talmanco
- Tardenafil
- Tildenafil
- Uk 336017
- Zydalis