CAS 171714-84-4

Darusentan

Description:

Darusentan is a selective endothelin receptor antagonist primarily targeting the endothelin A receptor. It is characterized by its ability to inhibit the action of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and potentially lowering blood pressure. This compound is often explored for its therapeutic potential in conditions such as hypertension and heart failure. Darusentan is typically administered orally and has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion. Its chemical structure features specific functional groups that contribute to its receptor-binding affinity and selectivity. The substance has undergone various clinical trials to assess its efficacy and safety profile, with a focus on cardiovascular health. As with many pharmacological agents, potential side effects may include fluid retention and changes in renal function, necessitating careful monitoring during treatment. Overall, darusentan represents a significant area of research in cardiovascular pharmacotherapy, particularly in managing conditions associated with elevated endothelin levels.

Formula: C₂₂H₂₂N₂O₆

InChI: InChI=1S/C22H22N2O6/c1-27-17-14-18(28-2)24-21(23-17)30-19(20(25)26)22(29-3,15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

InChI key: InChIKey=FEJVSJIALLTFRP-LJQANCHMSA-N

SMILES: C([C@H](OC=1N=C(OC)C=C(OC)N1)C(O)=O)(OC)(C2=CC=CC=C2)C3=CC=CC=C3

Synonyms:

• (2S)-2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
• (αS)-α-[(4,6-Dimethoxy-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid
• Benzenepropanoic acid, α-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (S)-
• Benzenepropanoic acid, α-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)-
• Darusentan
• Hmr-4005
• Lu-135252

Darusentan

CAS: 171714-84-4

Formula: C₂₂H₂₂N₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 410.4199

Ref: IN-DA00ACLF

(S)-2-((4,6-Dimethoxypyrimidin-2-Yl)Oxy)-3-Methoxy-3,3-Diphenylpropanoic Acid

CAS: 171714-84-4

(S)-2-((4,6-Dimethoxypyrimidin-2-Yl)Oxy)-3-Methoxy-3,3-Diphenylpropanoic Acid

Purity: 99%

Molecular weight: 410.42g/mol

Ref: 54-OR1025427

Darusentan

CAS: 171714-84-4

Darusentan

Purity: ≥95%

Molecular weight: 410.43g/mol

Ref: 54-BUP04764

Darusentan

CAS: 171714-84-4

Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries

Formula: C₂₂H₂₂N₂O₆

Purity: 98.72%

Color and Shape: Solid

Molecular weight: 410.43

Ref: TM-T5458