CAS 171887-03-9

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

Description:

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide, with the CAS number 171887-03-9, is a chemical compound characterized by its pyrimidine ring structure, which is substituted with two chlorine atoms and an amino group. This compound typically exhibits properties associated with heterocyclic compounds, including potential solubility in polar solvents due to the presence of the formamide functional group. The dichloro substitutions contribute to its reactivity and may influence its biological activity, making it of interest in pharmaceutical research. The amino group can participate in hydrogen bonding, enhancing its interactions in biological systems. Additionally, the compound may exhibit specific spectral characteristics in techniques such as NMR and IR spectroscopy, which can be utilized for its identification and characterization. Overall, its unique structure suggests potential applications in medicinal chemistry, particularly in the development of therapeutic agents targeting various biological pathways.

Formula: C₅H₄Cl₂N₄O

InChI: InChI=1S/C5H4Cl2N4O/c6-3-2(9-1-12)4(7)11-5(8)10-3/h1H,(H,9,12)(H2,8,10,11)

InChI key: InChIKey=XYWHZUCZNRMJGO-UHFFFAOYSA-N

SMILES: N(C=O)C=1C(Cl)=NC(N)=NC1Cl

Synonyms:

• 2,5-Diamino-4,6-DichloroformamidoHcl
• 2-Amino-4,6-dichloro-5-formamidopyrimidine
• 2-Amino-4,6-dichloro-5-pyrimidinyl formamide
• Formamide, N-(2-amino-4,6-dichloro-5-pyrimidinyl)-
• N-(2-Amino-4,6-Dichloro-5-Pyri
• N-(2-Amino-4,6-Dichloropyrimidin-5-Yl) Formamide
• N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
• N-2-AMINO-6-DICHLORO-5-PYRIMIDINYL)FORMAMIDE

2-Amino-4,6-dichloro-5-formamidopyrimidine

CAS: 171887-03-9

Formula: C₅H₄Cl₂N₄O

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 207.01

Ref: 3B-A2146

N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide

CAS: 171887-03-9

Formula: C₅H₄Cl₂N₄O

Purity: 95%

Color and Shape: Solid

Molecular weight: 207.0175

Ref: IN-DA0037PE

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

CAS: 171887-03-9

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

Purity: 98%

Molecular weight: 207.02g/mol

Ref: 54-OR1013950

N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide

CAS: 171887-03-9

Color and Shape: Neat

Ref: 86-MM3249.19

Abacavir Impurity 14

CAS: 171887-03-9

Formula: C₅H₄Cl₂N₄O

Molecular weight: 207

Ref: ST-EA-CP-A1037

N-(2-Amino-4,6-dichloropyrimidine-5-yl)formamide

CAS: 171887-03-9

Formula: C₅H₄Cl₂N₄O

Purity: 95%

Color and Shape: Solid, Yellow powder

Molecular weight: 207.01

Ref: 10-F076859

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

Controlled Product

CAS: 171887-03-9

Impurity Abacavir - In House Impurity
Applications N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formula: C₅H₄Cl₂N₄O

Color and Shape: Off-White To Beige

Molecular weight: 207.02

Ref: TR-A604735