CAS 17194-82-0

(4-Hydroxyphenyl)acetamide

Description:

(4-Hydroxyphenyl)acetamide, also known as paracetamol or acetaminophen, is an organic compound characterized by its aromatic structure and functional groups. It features a hydroxyl group (-OH) attached to a phenyl ring, which contributes to its solubility in water and its ability to form hydrogen bonds. The acetamide group (-NHCOCH3) enhances its pharmacological properties, making it a widely used analgesic and antipyretic agent. This compound is typically a white, crystalline solid with a melting point that varies depending on purity. It is known for its relatively low toxicity compared to other analgesics, making it suitable for over-the-counter use. In terms of reactivity, (4-Hydroxyphenyl)acetamide can undergo various chemical reactions, including acetylation and oxidation, and it is often involved in metabolic pathways in the human body. Its mechanism of action primarily involves the inhibition of cyclooxygenase enzymes, leading to reduced production of prostaglandins, which are mediators of pain and fever. Overall, its favorable safety profile and efficacy have made it a staple in pain management and fever reduction.

Formula: C₈H₉NO₂

InChI: InChI=1S/C8H9NO2/c9-8(11)5-6-1-3-7(10)4-2-6/h1-4,10H,5H2,(H2,9,11)

InChI key: InChIKey=YBPAYPRLUDCSEY-UHFFFAOYSA-N

SMILES: C(C(N)=O)C1=CC=C(O)C=C1

Synonyms:

• (4-Hydroxyphenyl)acetamide
• (p-Hydroxyphenyl)acetamide
• 2-(4-Hydroxyphenyl)Acetamide
• 2-(p-Hydroxyphenyl)acetamide
• 4-Hydroxyphenylacetamide
• Acetamide, 2-(p-hydroxyphenyl)-
• Benzeneacetamide, 4-hydroxy-
• NSC 187193
• P-Hydroxy Pheny lacetamide
• Para-Hydroxy Phenyl Acetamide
• Phpa
• p-(Carbamoylmethyl)phenol

4-Hydroxyphenylacetamide

CAS: 17194-82-0

Formula: C₈H₉NO₂

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 151.17

Ref: 3B-H0853

4-Hydroxyphenylacetamide, 99%

CAS: 17194-82-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₈H₉NO₂

Purity: 99%

Color and Shape: Pale cream to cream to pale brown, Crystals or powder or crystalline powder or lumps

Molecular weight: 151.17

Ref: 02-A15266

Atenolol Related Compound A (2-(4-Hydroxyphenyl)acetamide)

CAS: 17194-82-0

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Formula: C₈H₉NO₂

Color and Shape: Light Cream Powder

Molecular weight: 151.06333

Ref: 45-1044254

2-(4-Hydroxyphenyl)acetamide

CAS: 17194-82-0

Formula: C₈H₉NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 151.1626

Ref: IN-DA003LJP

(4-Hydroxyphenyl)acetamide

CAS: 17194-82-0

(4-Hydroxyphenyl)acetamide

Formula: C₈H₉NO₂

Purity: ≥95%

Color and Shape: faint yellow crystalline solid

Molecular weight: 151.16g/mol

Ref: 54-OR28890

4-Hydroxyphenylacetamide

CAS: 17194-82-0

4-Hydroxyphenylacetamide

Purity: ≥98%

Molecular weight: 151.165g/mol

Ref: 54-BUP15977

Atenolol EP Impurity A (Atenolol USP Related Compound A

CAS: 17194-82-0

Formula: C₈H₉NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 151.17

Ref: 4Z-A-112

4-Hydroxyphenylacetamide

CAS: 17194-82-0

Formula: C₈H₉NO₂

Molecular weight: 151.17

Ref: 7W-GK6981

4-Hydroxyphenylacetamide

CAS: 17194-82-0

4-Hydroxyphenylacetamide, HpdBCA decarboxylase inhibitor, is used as a whitening ingredient in cosmetics and skin care products.

Formula: C₈H₉NO₂

Purity: 99.75% - ≥98%

Color and Shape: White To Beige Powder

Molecular weight: 151.165

Ref: TM-Fr14145

2-(4-Hydroxyphenyl)acetamide

Controlled Product

CAS: 17194-82-0

Formula: C₈H₉NO₂

Color and Shape: Neat

Molecular weight: 151.16

Ref: 86-MM0013.03

Atenolol EP Impurity A

CAS: 17194-82-0

Formula: C₈H₉NO₂

Molecular weight: 151.17

Ref: ST-EA-CP-A29001

4-Hydroxyphenylacetamide

CAS: 17194-82-0

4-Hydroxyphenylacetamide is a natural product that has been shown to have antibiotic properties. It inhibits the growth of bacteria by inhibiting the synthesis of p-hydroxybenzoic acid, which is an essential precursor for the biosynthesis of aromatic amino acids and other important compounds. 4-Hydroxyphenylacetamide also inhibits dopamine oxidation, which may lead to its anti-infective properties. The biological properties of 4-hydroxyphenylacetamide have been studied using electrochemical impedance spectroscopy (EIS) on bacterial strains and in vitro studies on P. aeruginosa. This compound is not metabolized by microorganisms and does not mineralize or react with oxygen at physiological pH levels. It can be used as a pharmaceutical dosage form for treatment of infectious diseases.

Formula: C₈H₉NO₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 151.16 g/mol

Ref: 3D-FH37650

2-(4-Hydroxyphenyl)acetamide

CAS: 17194-82-0

Formula: C₈H₉NO₂

Purity: 98%

Color and Shape: Liquid, No data available.

Molecular weight: 151.165

Ref: 10-F219714

4-Hydroxyphenylacetamide

Controlled Product

CAS: 17194-82-0

Impurity Atenolol EP Impurity A
Applications 4-(Hydroxyphenyl)acetamide (Atenolol EP Impurity A) is used as an intermediate for the synthesis of Atenolol (A790075) and various other organic compounds and pharmaceuticals. It is a process impurity for Atenolol (A790075)
References Inkum, R., et al.: Maejo Int. J. Sci. Tech., 6, 372 (2012); Pai, N.R., et al.: J. Chem. Pharma. Rsch., 4, 375 (2012); Moon, J.T., et al.: Bio-org. Medn. Chem., 20, 734 (2012);

Formula: C₈H₉NO₂

Color and Shape: Neat

Molecular weight: 151.16

Ref: TR-H949045