CAS 17230-88-5

danazol

Description:

Danazol is a synthetic steroid with anti-estrogenic and androgenic properties, primarily used in the treatment of endometriosis and fibrocystic breast disease. Its chemical structure is characterized by a bicyclic compound that includes a cyclopentane ring fused to a cyclohexene ring, along with an amide functional group. Danazol acts by inhibiting the secretion of gonadotropins, thereby reducing estrogen production and altering the hormonal environment in the body. This results in the suppression of endometrial tissue growth. The substance is typically administered orally and is known for its relatively low side effect profile compared to other hormonal therapies, although it can still cause androgenic effects such as weight gain, acne, and voice changes. Danazol is classified under the category of synthetic androgens and is recognized for its unique mechanism of action, making it a valuable option in managing certain gynecological conditions. Its pharmacokinetics involve extensive hepatic metabolism, and it is important to monitor liver function during treatment.

Formula: C₂₂H₂₇NO₂

InChI: InChI=1/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20?,21?,22+/m1/s1

InChI key: InChIKey=POZRVZJJTULAOH-LHZXLZLDSA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@](C#C)(O)CC4)[H])(CCC1=CC5=C(C2)C=NO5)[H])[H]

Synonyms:

• (1R,10aR,12aS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol
• (1R,3aS,3bR,10aR,10bS,12aS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d][1,2]oxazol-1-ol
• (1R,3aS,3bR,10bS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d][1,2]oxazol-1-ol
• 17-Alpha-2,4-Pregnadien-20-Yno(2,3-D)Isoxazol-17-Ol
• 17-Alpha-Pregn-4-En-20-Yno(2,3-D)Isoxazol-17-Ol
• 17α-Pregna-2,4-dien-20-yne-[2,3-d]isoxazole-17β-ol
• 17α-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol
• 1H-Cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol, 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-
• 1H-Cyclopenta[7,8]phenanthro[3,2-d]isoxazole, pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol deriv.
• 3-D)Isoxazol-17-Ol,(17-Alpha)-Pregna-4-Dien-20-Yno(2
• Bonzol
• Chronogyn
• Cyclomen
• Danalem
• Danatrol
• Danazole
• Danazolum
• Danocrine
• Danol
• Danovaol
• Danzol
• Hydrocortisonum micr.
• Ladogal
• Nsc 270916
• Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, (17α)-
• Win 17757
• Win17757
• Winobanin
• (17R)-Pregn-2-eno[2,3-d]isoxazol-4-en-20-yn-17-ol
• 2,4,17α-Pregnadien-20-yno[2,3-d]isoxazol-17-ol, 17β-Hydroxy-2,4,17α-pregnadien-20-yno[2,3-d]isoxazole
• DANAZOL
• Danazol (200 mg)
• 17β-Hydroxy-2,4,17α-pregnadien-20-yno[2,3-d]isoxazole
• 17a-Ethynyl-17b-hydroxy-4-androsteno[2,3-d]isoxazole
• 1H-Cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol, 1-ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-(7CI)
• DANAZOL((17ALPHA)-PREGNA-2,4-DIEN-20-YNO[2,3-D]ISOXAZOL-17-OL)
• 2,4,17-ALPHA-PREGNADIEN-20-YNO[2,3-D]ISOXAZOL-17-OL
• 17b-Hydroxy-2,4,17a-pregnadien-20-yno[2,3-d]isoxazole
• DanazolUspC22H27No2
• Danazol Solution, 100ppm
• DANAZOL >98% ANTERIOR PITUITARY SU
• 17BETA-HYDROXY-2,4,17ALPHA-PREGNADIEN-20-YNO[2,3-D]ISOXAZOLE
• 17α-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol (8CI)
• 4-ANDROSTEN-[2,3-D]ISOXAZOLE-17-ALPHA-ETHYNYL-17-BETA-OL
• Dano
• Danazol,17β-Hydroxy-2,4,17α-pregnadien-20-yno[2,3-d]isoxazole, 2,4,17α-Pregnadien-20-yno[2,3-d]-isoxa-zol-17-ol
• 17a-Ethynyl-17-hydroxy-4-androsteno[2,3-d]isoxazole
• Danazol Usp
• 2,4,17α-Pregnadien-20-yno[2,3-d]isoxazol-17-ol
• 17α-Ethynyl-17β hydroxy-4-androsteno[2,3-d]isoxazole

Danazol

CAS: 17230-88-5

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₂H₂₇NO₂

Color and Shape: White Pale Yellow Crystalline Powder

Molecular weight: 337.20418

Ref: 45-1162501

Danazol

Controlled Product

CAS: 17230-88-5

Formula: C₂₂H₂₇NO₂

Color and Shape: Neat

Molecular weight: 337.46

Ref: 04-C11960300

Danazol

CAS: 17230-88-5

Formula: C₂₂H₂₇NO₂

Molecular weight: 337.46

Ref: 4Z-D-217001

Danazol RS

CAS: 17230-88-5

Color and Shape: White

Ref: 2K-1078600021

Danazol

Controlled Product

CAS: 17230-88-5

Applications Danazol is an anterior pituitary supressant. Danazol is an anabolic steroid derivative of ethisterone, with mild androgenic side effects (an impeded androgen). Antigonadotropin.
References Ahn, Y.S., et al.: N. Engl. J. Med., 308, 1396 (1983),

Formula: C₂₂H₂₇NO₂

Color and Shape: White To Light Yellow

Molecular weight: 337.46

Ref: TR-D145000

Danazol-13C3

Controlled Product

CAS: 17230-88-5

Applications An isotopically labelled analog of Danazol, an anterior pituitary supressant. Anabolic steroid derivative of ethisterone, with mild androgenic side effects (an impeded androgen). Antigonadotropin.
References Ahn, Y.S., et al.: N. Engl. J. Med., 308, 1396 (1983),

Formula: C₁₉₁₃C₃H₂₇NO₂

Color and Shape: Neat

Molecular weight: 340.43

Ref: TR-D145002

Danazol (1 mg/mL in acetonitrile)

Controlled Product

CAS: 17230-88-5

Formula: C₂₂H₂₇NO₂

Color and Shape: Single Solution

Molecular weight: 337.46

Ref: TR-KIT0050

Danazol, USP

CAS: 17230-88-5

Formula: C₂₂H₂₇NO₂

Color and Shape: Solid

Molecular weight: 337.4553

Ref: IN-DA003P8F

Danazol

Controlled Product

CAS: 17230-88-5

Anti-gonadotropin; therapy for endometriosis

Formula: C₂₂H₂₇NO₂

Purity: (Uv) Reported (%)

Molecular weight: 337.46 g/mol

Ref: 3D-FD156781