CAS 172361-60-3

5'-O-(Dimethoxytrityl)-N2-(Dimethylaminomethylidene)-3'-Deoxyguanosine

Description:

5'-O-(Dimethoxytrityl)-N2-(Dimethylaminomethylidene)-3'-Deoxyguanosine is a modified nucleoside that plays a significant role in nucleic acid chemistry, particularly in the synthesis of oligonucleotides. This compound features a deoxyguanosine backbone, which is a component of DNA, and is modified at the 5' position with a dimethoxytrityl (DMT) group, enhancing its stability and solubility during synthesis. The N2 position is substituted with a dimethylaminomethylidene group, which can influence the reactivity and binding properties of the nucleoside. Such modifications are crucial for the development of nucleic acid-based therapeutics and molecular probes. The presence of the DMT group allows for easy purification and characterization of the oligonucleotide products, while the dimethylaminomethylidene moiety may enhance the compound's ability to form stable interactions with complementary nucleic acids. Overall, this compound exemplifies the strategic modifications used in nucleoside chemistry to improve the performance of oligonucleotides in various applications, including gene therapy and molecular diagnostics.

Formula: C₃₄H₃₆N₆O₆

Synonyms:

• DMT-DMF-dG

5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-3'-DEOXYGUANOSINE

CAS: 172361-60-3

Formula: C₃₄H₃₆N₆O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 624.6862

Ref: IN-DA007D1Z

DMT-DMF-dG

CAS: 172361-60-3

DMT-DMF-dG

Purity: 97%

Molecular weight: 624.7g/mol

Ref: 54-OR1055689

3''-Deoxy-N2-DMF-5''-O-DMT-guanosine

CAS: 172361-60-3

Ref: 7W-GN7904

3'-Deoxy-N2-DMF-5'-O-DMT-guanosine

CAS: 172361-60-3

3'-Deoxy-N2-DMF-5'-O-DMT-guanosine is a modified nucleoside that is phosphorylated to the 3'-deoxyribonucleotide form. It has antiviral and anticancer activities, as well as being an activator of DNA and RNA synthesis. This compound has been shown to inhibit the growth of several cancer cell lines in vitro and in vivo. 3'-Deoxy-N2-DMF-5'-O-DMT-guanosine is also effective against herpes simplex virus type 1 (HSV1) and HSV type 2 in cell culture, although it does not have any effect on HSV type 1 replication in animal models.

Formula: C₃₄H₃₆N₆O₆

Purity: Min. 95%

Molecular weight: 624.69 g/mol

Ref: 3D-NB161196