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CAS 172451-37-5

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Imperatoxin A

Description:
Imperatoxin A is a potent neurotoxin derived from the venom of the African scorpion species, Pandinus imperator. It is classified as a polypeptide and is known for its ability to selectively bind to voltage-gated sodium channels, particularly the Nav1.2 subtype, which plays a crucial role in the propagation of action potentials in neurons. This binding disrupts normal ion flow, leading to prolonged depolarization and increased excitability of nerve cells. Imperatoxin A exhibits a high degree of specificity and potency, making it a valuable tool in neuropharmacology for studying sodium channel function and potential therapeutic applications. The substance is characterized by its complex structure, which includes multiple disulfide bonds that contribute to its stability and biological activity. Due to its toxic nature, research involving Imperatoxin A requires careful handling and adherence to safety protocols. Its unique mechanism of action has also sparked interest in the development of novel analgesics and treatments for neurological disorders.
Formula:C148H260N58O45S6
Synonyms:
  • Iptxa
  • Imperatoxin A, Pandinus Imperator
  • H-Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Arg-Cys-Lys-Ala-Asp-Asn-Asp-Cys-Cys-Gly-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ala-Glu-Lys-Arg-Cys-Arg-Oh
  • H-Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Arg-Cys-Lys-Ala-Asp-Asn-Asp-Cys-Cys-Gly-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ala-Glu-Lys-Arg-Cys-Arg-Oh (Disulfide Bonds Undetermined)
  • Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Arg-Cys-Lys-Ala-Asp-Asn-Asp-Cys-Cys-Gly-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ala-Glu-Lys-Arg-Cys-Arg
  • Ptx(A)
  • H-Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Arg-Cys-Lys-Ala-Asp-Asn-Asp-Cys-Cys-Gly-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ala-Glu-Lys-Arg-Cys-Arg-OH (Disulfide bridges are not determined)
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Found 3 products.
  • CymitQuimica logo
    Glentham
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    Imperatoxin A

    CAS:
    Formula:C148H260N58O45S6
    Molecular weight:3764.40

    Ref: 7W-GK3701

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  • CymitQuimica logo
    Targetmol
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    Imperatoxin A

    CAS:
    Imperatoxin A, a peptide toxin sourced from the African scorpion Pandinus imperator, functions as an activator of Ca2+-release channels/ryanodine receptors (
    Formula:C148H254N58O45S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3758.35

    Ref: TM-T80063

  • Imperatoxin A
    Biosynth
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    Imperatoxin A

    CAS:
    <p>A synthetic scorpion toxin consisting of disulfide bonds between Cys3-Cys17, Cys10-Cys21, and Cys16-Cys32. It can be used as an activator of Ca2+ Release Channels/Ryanodine Receptors. It is important to understand the functions of Ryanodine receptors as they mediate Ca2+ release from intracellular reticular stores and this is imperative for signalling processes, namely muscle excitation-contraction coupling. If skeletal and cardiac Ryanodine receptor genes are mutated diseases such as congenital myopathy and metabolic disorders occur. Therefore Imperatoxin A is useful in investigating these diseases. This product is avaiable as a 0.1mg vial.</p>
    Formula:C148H254N58O45S6
    Purity:Min. 95%
    Molecular weight:3,758.4 g/mol

    Ref: 3D-PIM-4343-S

    100µg
    847.00€