CAS 172546-75-7

his-cys-lys-phe-trp-trp

Description:

The chemical substance known as "his-cys-lys-phe-trp-trp" is a peptide composed of six amino acids: histidine (His), cysteine (Cys), lysine (Lys), phenylalanine (Phe), and tryptophan (Trp), with tryptophan appearing twice. This peptide is characterized by its diverse functional groups, which contribute to its biochemical properties, such as solubility, reactivity, and potential biological activity. The presence of aromatic amino acids like phenylalanine and tryptophan may impart UV absorbance characteristics, while the cysteine residue can form disulfide bonds, influencing the peptide's three-dimensional structure and stability. The sequence of amino acids suggests potential roles in biological processes, including signaling, enzyme activity, or as a building block for larger proteins. The CAS number 172546-75-7 uniquely identifies this specific peptide in chemical databases, facilitating its study and application in research, pharmaceuticals, or biotechnology. Overall, this peptide's characteristics make it a subject of interest in various fields, including biochemistry and molecular biology.

Formula: C₄₆H₅₅N₁₁O₇S

Synonyms:

• H-His-Cys-Lys-Phe-Trp-Trp-OH

H-His-Cys-Lys-Phe-Trp-Trp-OH

CAS: 172546-75-7

HCKFWW, potent inhibitor of the HIV-encoded integrase (IN), the enzyme responsible for the integration of HIV DNA into the human genome. HCKFWW inhibits IN-mediated 3’processing and integration with an IC₅₀ of 2 µM. The peptide is also active on IN proteins from other retroviruses such as HIV-2, feline immunodeficiency virus and Moloney murine leukemia virus. It was also found to inhibit the disintegration reaction, suggesting that this hexapeptide acts at or near the catalytic site of IN.

Formula: C₄₆H₅₅N₁₁O₇S

Purity: 97.9%

Color and Shape: White Lyophilisate

Molecular weight: 906.08

Ref: 01-4026848

His-Cys-Lys-Phe-Trp-Trp

CAS: 172546-75-7

His-Cys-Lys-Phe-Trp-Trp functions as an inhibitor of the human immunodeficiency virus (HIV) integrase, exhibiting an IC50 value of 2 μM.

Formula: C₄₆H₅₅N₁₁O₇S

Color and Shape: Solid

Molecular weight: 906.06

Ref: TM-TP2672

His-Cys-Lys-Phe-Trp-Trp

CAS: 172546-75-7

Formula: C₄₆H₅₅N₁₁O₇S

Molecular weight: 906.07

Ref: 7W-GK1238

His-Cys-Lys-Phe-Trp-Trp

CAS: 172546-75-7

His-Cys-Lys-Phe-Trp-Trp is a tryptic peptide, which is a fragment of the human immunodeficiency virus (HIV) p24 protein. This peptide has been shown to inhibit HIV replication in vitro. His-Cys-Lys-Phe-Trp-Trp binds to the transfer RNA and prevents the amino acid transfer reaction from occurring. The binding of His-Cys-Lys-Phe-Trp-Trp to glutathione may be due to its hydrophilicity, which allows it to interact with this molecule. His-Cys-Lys-Phe-Trp also interacts with reactive oxygen species, which are generated as byproducts of glutathione metabolism.

Formula: C₄₆H₅₅N₁₁O₇S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 906.06 g/mol

Ref: 3D-FH73444