CAS 172666-82-9

Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH

Description:

The chemical substance known as Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH, with the CAS number 172666-82-9, is a synthetic peptide that consists of a specific sequence of amino acids. It features a combination of both hydrophobic and hydrophilic residues, which contributes to its potential biological activity and interaction with various receptors or enzymes. The presence of the Dnp (dinitrophenyl) group indicates that this peptide may be used in studies related to protein labeling or as a marker in biochemical assays. The sequence includes arginine, proline, leucine, alanine, tryptophan, and serine, which are known for their roles in protein structure and function. The peptide's structure suggests it may exhibit specific conformational properties that could influence its biological activity, such as binding affinity or enzymatic activity. Additionally, the C-terminal hydroxyl group (OH) indicates that it may be involved in further chemical modifications or interactions. Overall, this peptide is of interest in biochemical research, particularly in studies involving peptide synthesis, protein interactions, and therapeutic applications.

Formula: C₅₂H₇₇N₁₇O₁₄

Synonyms:

• Pump-1 Substrate
• Mmp-7 Substrate, Fluorogenic
• 360 Mmp Fret Substrate V
• Matrilysin Substrate
• Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser
• Dnp-Rplalwrs

Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH

CAS: 172666-82-9

The enzyme DNP-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser (DAPPLE) is a zymogen that is activated by proteolytic cleavage to form an active enzyme. DAPPLE has been shown to cause neuronal death in vitro. The enzyme can be inhibited by the addition of specific inhibitors, such as 4-(2-aminoethyl)benzenesulfonyl fluoride, which blocks the activity of matrix metalloproteinases. DAPPLE has been found in mammalian ovaries and induces the release of growth factors when it is activated by proteolytic cleavage. The optimum pH for DAPPLE activity is 7.5 and it can be inhibited by the addition of certain drugs, such as phenylmethylsulfonyl fluoride or sodium azide.

Formula: C₅₂H₇₇N₁₇O₁₄

Purity: Min. 95%

Molecular weight: 1,164.3 g/mol

Ref: 3D-MMP-3072-PI

Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH trifluoroacetate salt

CAS: 172666-82-9

Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH trifluoroacetate salt is a potent, competitive inhibitor of matrix metalloproteinase (MMP) 3 and MMP9. It binds to the catalytic zinc ion in the active site of these enzymes. Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH trifluoroacetate salt has been shown to inhibit tumor growth and promote neuronal death in vitro. This drug also blocks the release of matrix metalloproteins from cells, which are involved in extracellular processes such as cell migration and cell adhesion.

Formula: C₅₂H₇₇N₁₇O₁₄

Purity: Min. 95%

Molecular weight: 1,164.27 g/mol

Ref: 3D-FD110928