CAS 172927-65-0

Sibrafiban

Description:

Sibrafiban is a synthetic compound classified as a fibrinogen receptor antagonist, primarily used in the context of cardiovascular medicine. It functions by inhibiting platelet aggregation, which can be beneficial in preventing thrombotic events such as heart attacks and strokes. The substance is characterized by its ability to selectively bind to the glycoprotein IIb/IIIa receptor on platelets, thereby blocking the binding of fibrinogen and other adhesive proteins that facilitate platelet aggregation. Sibrafiban is typically administered in a clinical setting, and its pharmacokinetics involve rapid absorption and metabolism. The compound has been studied for its efficacy in various clinical trials, particularly in patients with acute coronary syndromes. As with many pharmacological agents, potential side effects may include bleeding complications, which necessitate careful monitoring during treatment. Overall, Sibrafiban represents a significant advancement in antiplatelet therapy, contributing to improved outcomes in patients at risk for thrombotic cardiovascular events.

Formula: C₂₀H₂₈N₄O₆

InChI: InChI=1S/C20H28N4O6/c1-3-29-17(25)12-30-16-8-10-24(11-9-16)20(27)13(2)22-19(26)15-6-4-14(5-7-15)18(21)23-28/h4-7,13,16,28H,3,8-12H2,1-2H3,(H2,21,23)(H,22,26)

InChI key: InChIKey=WBNUCLPUOSXSNJ-UHFFFAOYSA-N

SMILES: C(C(NC(=O)C1=CC=C(C(=NO)N)C=C1)C)(=O)N2CCC(OCC(OCC)=O)CC2

Synonyms:

• Sibrafiban
• Acetic acid, 2-[[1-[(2S)-2-[[4-[(Z)-amino(hydroxyimino)methyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-, ethyl ester
• Ro 48-3657/001
• Acetic acid, [[1-[2-[[4-[amino(hydroxyimino)methyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-, ethyl ester, [S-(Z)]-
• Acetic acid, [[1-[(2S)-2-[[4-[(Z)-amino(hydroxyimino)methyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-, ethyl ester

Sibrafiban

CAS: 172927-65-0

Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.

Formula: C₂₀H₂₈N₄O₆

Color and Shape: Solid

Molecular weight: 420.46

Ref: TM-T28775