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CAS 172998-24-2

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buforin ii

Description:
Buforin II is a peptide derived from the skin of the Asian toad, Bufo bufo gargarizans, and is known for its antimicrobial properties. It is composed of a sequence of amino acids that contribute to its ability to disrupt microbial membranes, making it a subject of interest in pharmaceutical research, particularly for its potential as an antibiotic agent. Buforin II exhibits a cationic nature, which enhances its interaction with negatively charged bacterial membranes. This peptide is characterized by its relatively small size and a high degree of structural flexibility, which is essential for its biological activity. Additionally, buforin II has been studied for its potential applications in cancer therapy due to its ability to induce apoptosis in certain cancer cell lines. Its stability and efficacy in various biological environments are areas of ongoing research, as scientists explore its potential therapeutic uses and mechanisms of action. Overall, buforin II represents a promising candidate in the field of antimicrobial and anticancer research.
Formula:C106H184N40O26
InChI:InChI=1/C97H175N39O25/c1-47(2)37-62(122-71(142)42-117-75(143)52(11)120-76(144)56(23-16-32-113-94(103)104)125-85(153)66(44-137)133-86(154)67(45-138)132-79(147)59(26-19-35-116-97(109)110)126-88(156)72(100)53(12)139)81(149)127-60(28-29-69(99)140)91(159)136-36-20-27-68(136)87(155)135-73(50(7)8)89(157)118-43-70(141)121-55(22-15-31-112-93(101)102)80(148)134-74(51(9)10)90(158)131-65(40-54-41-111-46-119-54)84(152)124-58(25-18-34-115-96(107)108)78(146)129-64(39-49(5)6)83(151)130-63(38-48(3)4)82(150)123-57(24-17-33-114-95(105)106)77(145)128-61(92(160)161)21-13-14-30-98/h41,46-53,55-68,72-74,137-139H,13-40,42-45,98,100H2,1-12H3,(H2,99,140)(H,111,119)(H,117,143)(H,118,157)(H,120,144)(H,121,141)(H,122,142)(H,123,150)(H,124,152)(H,125,153)(H,126,156)(H,127,149)(H,128,145)(H,129,146)(H,130,151)(H,131,158)(H,132,147)(H,133,154)(H,134,148)(H,135,155)(H,160,161)(H4,101,102,112)(H4,103,104,113)(H4,105,106,114)(H4,107,108,115)(H4,109,110,116)/t52-,53?,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,72-,73-,74-/m0/s1
SMILES:CC(C)C[C@@H](C(=N[C@@H](CCC(=N)O)C(=O)N1CCC[C@H]1C(=N[C@@H](C(C)C)C(=NCC(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CC(C)C)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(CN=C([C@H](C)N=C([C@H](CCCNC(=N)N)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](CCCNC(=N)N)N=C([C@H](C(C)O)N)O)O)O)O)O)O)O
Synonyms:
  • Thr-Arg-Ser-Ser-Arg-Ala-Gly-Leu-Gln-Phe-Pro-Val-Gly-Arg-Val-His-Arg-Leu-Leu-Arg-Lys
  • Buforin II
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  • Buforin II
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    Buforin II

    CAS:
    <p>Buforin II is a highly potent antimicrobial peptide which was derived from buforin I, a peptide isolated from the stomach of the Asian toad, Bufo bufo garagrizans. Buforin II is an alpha-helical antimicrobial peptide, however it has far stronger antimicrobial activity against a broad spectrum of microorganisms compared with other alpha-helical antimicrobial peptides. Buforin II may have a different mode of action to that of other alpha-helical peptides targeting nucleic acids instead of cell membranes.</p>
    Formula:C106H184N40O26
    Color and Shape:Powder
    Molecular weight:2,434.85 g/mol

    Ref: 3D-CRB1000166

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    500µg
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