CAS 17320-10-4
:4β-Hydroxycholesterol
Description:
4β-Hydroxycholesterol is a sterol compound that is a derivative of cholesterol, characterized by the presence of a hydroxyl group at the 4β position of the steroid nucleus. This compound is of interest in biochemistry and pharmacology due to its role in cholesterol metabolism and its potential implications in various physiological processes. It is produced in the body through the enzymatic action of cytochrome P450 enzymes, particularly CYP3A4. 4β-Hydroxycholesterol has been studied for its effects on cholesterol homeostasis and its potential as a biomarker for cholesterol synthesis. It is generally found in low concentrations in human plasma and is thought to influence lipid metabolism and inflammatory responses. The compound is also being investigated for its potential role in cardiovascular health and disease. As with many sterols, its solubility is limited in water but it can be dissolved in organic solvents. Safety and handling precautions should be observed when working with this compound, as with all chemical substances.
Formula:C27H46O2
InChI:InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1
InChI key:InChIKey=CZDKQKOAHAICSF-JSAMMMMSSA-N
SMILES:C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC=C1[C@@H](O)[C@@H](O)CC2)[H])[H]
Synonyms:- (3β,4β)-Cholest-5-ene-3,4-diol
- 3β,4β-Dihydroxycholest-5-ene
- 4β-Hydroxycholesterol
- 5-Cholesten-3-Beta, 4-Beta-Diol
- Cholest-5-Ene-3,4-Diol
- Cholest-5-ene-3,4-diol, (3β,4β)-
- Cholest-5-ene-3β,4β-diol
- cis-3,4-Dihydroxy-Δ<sup>5</sup>-cholestene
- cis-Δ<sup>5</sup>-Cholestene-3,4-diol
Sort by
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Found 8 products.
Cholest-5-ene-3,4-diol, (3β,4β)-
CAS:Formula:C27H46O2Purity:98%Color and Shape:SolidMolecular weight:402.65294-β-Hydroxy Cholesterol
CAS:Formula:C27H46O2Color and Shape:White To Off-White SolidMolecular weight:402.664β-hydroxy Cholesterol
CAS:<p>4β-hydroxy Cholesterol is a useful organic compound for research related to life sciences. The catalog number is T21530 and the CAS number is 17320-10-4.</p>Color and Shape:SolidMolecular weight:402.653Cholesterol Impurity 10
CAS:Formula:C27H43BrOColor and Shape:White To Off-White SolidMolecular weight:463.544β-Hydroxy Cholesterol
CAS:Controlled Product<p>Applications A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.<br>References Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995), Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1998), Chawla, A., et al.: Science, 294, 1866 (2001), Bodin, K., et al.: J. Biol. Chem., 276, 38685 (2001),<br></p>Formula:C27H46O2Color and Shape:White To Light BeigeMolecular weight:402.654b-Hydroxy cholesterol
CAS:Controlled Product<p>4b-Hydroxy cholesterol is a sterol that is found in human serum and rat liver microsomes. It has been shown to be a potent inducer of CYP3A4, which is an important enzyme in the metabolism of many drugs. 4b-Hydroxy cholesterol has also been shown to induce transcriptional regulation by binding to the sterol regulatory element binding protein (SREBP) and activating it. This activation results in the increased production of cholesterol and other sterols by upregulating transcription of genes that are involved in cholesterol synthesis. 4b-Hydoxy cholesterol has been shown to have anti-inflammatory properties due to its inhibition of triclosan and clinical studies show that it can reduce serum levels of total cholesterol and low density lipoprotein (LDL) cholesterol in women.</p>Formula:C27H46O2Purity:Min. 95%Molecular weight:402.65 g/mol
