CAS 173326-37-9

N-CIS-2,6-DIMETHYLPIPERIDINOCARBONYL-BETA-TBU-ALA-D-TRP(1-METHOXYCARBONYL)-D-NLE-OH

Description:

N-CIS-2,6-Dimethylpiperidinocarbonyl-beta-t-butylalanine-D-tryptophan(1-methoxycarbonyl)-D-norleucine-OH, identified by its CAS number 173326-37-9, is a synthetic compound that belongs to the class of peptides and peptide analogs. This substance features a complex structure characterized by a piperidine ring, which contributes to its cyclic nature and potential biological activity. The presence of multiple functional groups, including carbonyl and methoxycarbonyl moieties, suggests that it may exhibit specific interactions with biological targets, potentially influencing its pharmacological properties. The incorporation of amino acid residues such as beta-t-butylalanine, D-tryptophan, and D-norleucine indicates that this compound may be designed for specific receptor binding or enzyme inhibition. Its stereochemistry, particularly the cis configuration, may also play a crucial role in its biological activity and stability. Overall, this compound's unique structural features make it a subject of interest in medicinal chemistry and drug development, particularly in the context of designing novel therapeutic agents.

BQ-788

CAS: 173326-37-9

Bachem ID: 4102091.

Formula: C₃₄H₅₁N₅O₇

Purity: 97.0%

Molecular weight: 641.81

Ref: 01-4102091

BQ-788

CAS: 173326-37-9

In vitro, BQ-788 potently and competitively inhibited ¹²⁵I-labeled ET-1 binding to ET-B receptors on human Girardi heart cells (IC₅₀= 1.2 nM). However, BQ-788 only poorly inhibited ET-1 binding to ET-A receptors on human neuroblastoma cell line SK-N-MC cells (IC₅₀= 1300 nM). Thus the ET-B receptor antagonist BQ788 may be considered as a powerful tool for investigating the role of ET in physiological and pathological processes.

Formula: C₃₄H₅₁N₅O₇

Purity: 95.3%

Color and Shape: White Powder

Molecular weight: 641.81

Ref: 01-4026108

N-CIS-2,6-DIMETHYLPIPERIDINOCARBONYL-β-TBU-ALA-D-TRP(1-METHOXYCARBONYL)-D-NLE-OH

CAS: 173326-37-9

Formula: C₃₄H₅₁N₅O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 641.7980

Ref: IN-DA00ABN8

BQ-788

CAS: 173326-37-9

BQ-788

Purity: ≥98%

Molecular weight: 641.8g/mol

Ref: 54-BUP07009

BQ-788

CAS: 173326-37-9

BQ-788 is a drug with an antagonist activity at the endothelin receptor. It has been shown to have a physiological effect on humans, and it has been shown to inhibit the production of endothelin-1 in the rat ileum. BQ-788 was also found to inhibit cyclase activity in vitro and to increase cytosolic calcium levels. This drug has been shown to decrease blood pressure in rats, which may be due to its inhibition of angiotensin II receptors.

Formula: C₃₄H₅₁N₅O₇

Purity: Min. 95%

Molecular weight: 641.8 g/mol

Ref: 3D-FB108685

BQ-788

CAS: 173326-37-9

BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.

Formula: C₃₄H₅₁N₅O₇

Purity: 98.81%

Color and Shape: Solid

Molecular weight: 641.8

Ref: TM-T10595