CAS 173334-57-1

Aliskiren

Description:

Aliskiren is a pharmaceutical compound classified as a direct renin inhibitor, primarily used in the treatment of hypertension. Its mechanism of action involves the inhibition of renin, an enzyme that plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance. Aliskiren is characterized by its relatively low solubility in water, which can affect its bioavailability and absorption. The compound is typically administered orally and is known for its long half-life, allowing for once-daily dosing. Aliskiren is often used alone or in combination with other antihypertensive agents to achieve better blood pressure control. Common side effects may include gastrointestinal disturbances, headache, and dizziness. As with other medications affecting the RAAS, caution is advised in patients with renal impairment or those who are pregnant, as it may pose risks to fetal development. Overall, Aliskiren represents a novel approach to managing hypertension by targeting the early stages of the RAAS pathway.

Formula: C₃₀H₅₃N₃O₆

InChI: InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1

InChI key: InChIKey=UXOWGYHJODZGMF-QORCZRPOSA-N

SMILES: O(CCCOC)C1=C(OC)C=CC(C[C@@H](C[C@@H]([C@H](C[C@H](C(NCC(C(N)=O)(C)C)=O)C(C)C)O)N)C(C)C)=C1

Synonyms:

• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxo-propyl)-4-hydroxy-2-isopropyl-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-nonanamide hydrochloride
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamide
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(1-methylethyl)nonanamide (2E)-but-2-enedioate (salt)
• (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide
• (2S,4S,5S,7S)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide
• (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide
• (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, [αS-(αR*,γR*,δR*,ζR*)]-
• Cgp 60536
• Cgp60536B
• Enviage
• Rasilez
• Riprazo
• Spp 100
• Sprimeo
• Tekturna

5-Amino-n-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate

CAS: 173334-57-1

Formula: C₃₀H₅₃N₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 551.7583

Ref: IN-DA001YTA

Aliskiren

CAS: 173334-57-1

Aliskiren

Purity: ≥95%

Molecular weight: 551.76g/mol

Ref: 54-BUP12969

Aliskiren

CAS: 173334-57-1

Formula: C₃₀H₅₃N₃O₆

Molecular weight: 551.76

Ref: 7W-GP7354

Aliskiren

CAS: 173334-57-1

Aliskiren (CGP 60536) is a renin inhibitor (IC50: 1.5 nM) with antihypertensive activity and is used in the treatment of various cardiovascular diseases.

Formula: C₃₀H₅₃N₃O₆

Purity: 97.02%

Color and Shape: Solid

Molecular weight: 551.76

Ref: TM-T22233

5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumar ate

CAS: 173334-57-1

5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumar ate is a drug that inhibits the activity of angiotensin II, which is a hormone produced by the body. It is used as monotherapy for treatment of hypertension. 5AMINO has been shown to be effective in lowering blood pressure when administered alone and has been shown to be well tolerated. For this drug, the most frequently reported adverse reactions are nausea and dizziness. This drug should not be taken with other antihypertensive drugs or nonsteroidal antiinflammatory drugs such as ibuprofen (Motrin®). In addition, patients with diabetes should monitor their blood sugar levels carefully while taking this medication.

Formula: C₃₀H₅₃N₃O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 551.76 g/mol

Ref: 3D-FA134549

ALISKIREN

CAS: 173334-57-1

Purity: 98%

Molecular weight: 551.7689819

Ref: 10-F793779