CAS 173334-58-2

Aliskiren hemifumarate

Description:

Aliskiren hemifumarate is a pharmaceutical compound primarily used as an antihypertensive agent. It functions as a direct renin inhibitor, which helps to lower blood pressure by preventing the conversion of angiotensinogen to angiotensin I, thereby reducing the production of angiotensin II, a potent vasoconstrictor. This compound is characterized by its relatively high solubility in water, which facilitates its absorption in the gastrointestinal tract. Aliskiren hemifumarate is typically administered orally and is known for its long half-life, allowing for once-daily dosing. The hemifumarate form indicates that it is a salt derived from fumaric acid, which can enhance its stability and solubility. Common side effects may include gastrointestinal disturbances, headache, and dizziness. As with any medication, it is essential to consider contraindications and potential interactions with other drugs. Overall, Aliskiren hemifumarate represents a significant advancement in the management of hypertension, providing an alternative to traditional therapies.

Formula: C₃₀H₅₃N₃O₆C₄H₄O₄

InChI: InChI=1/2C30H53N3O6.C4H4O4/c2*1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36;5-3(6)1-2-4(7)8/h2*10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*22-,23-,24-,25-;/m00./s1

SMILES: O(CCCOC)C1=C(OC)C=CC(C[C@@H](C[C@@H]([C@H](C[C@H](C(NCC(C(N)=O)(C)C)=O)C(C)C)O)N)C(C)C)=C1.C(=C/C(O)=O)\C(O)=O

Synonyms:

• (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumarate
• (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxo-propyl)-4-hydroxy-2-isopropyl-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-nonanamide
• Aliskiren Fumarate
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1)
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1) (salt)
• Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, [αS-(αR*,γR*,δR*,ζR*)]-, (E)-2-butenedioate (2:1) (salt)
• But-2-Enedioic Acid
• Aliskiren hemifumarate

Aliskiren hemifumarate

CAS: 173334-58-2

Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.

Formula: C₃₀H₅₃N₃O₆C₄H₄O₄

Purity: 96.18% - 99.21%

Color and Shape: Solid

Molecular weight: 1219.6

Ref: TM-T1520

(2E)-but-2-enedioic acid; bis((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide)

CAS: 173334-58-2

Formula: C₆₄H₁₁₀N₆O₁₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 1219.5888

Ref: IN-DA001YT9

Aliskiren Hemifumarate

CAS: 173334-58-2

Aliskiren Hemifumarate

Purity: 98%

Molecular weight: 667.83g/mol

Ref: 54-OR1027363

Aliskiren hemifumarate

CAS: 173334-58-2

Aliskiren hemifumarate

Purity: ≥95%

Molecular weight: 1219.6g/mol

Ref: 54-BUP13287

Aliskiren Hemifumarate

CAS: 173334-58-2

Formula: C₃₀H₅₃N₃O₆·5C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 551.77 0.5*116.07

Ref: 4Z-A-711

Aliskiren-d6 Hemifumarate

CAS: 173334-58-2

Formula: C₃₀H₄₇D₆N₃O₆·5C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 557.81 0.5*116.07

Ref: 4Z-A-712

Aliskiren Hemifumarate

CAS: 173334-58-2

Formula: C₆₀H₁₀₆N₆O₁₂·C₄H₄O₄

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 1,219.61

Ref: 3B-A3624

Aliskiren hemifumarate - Bio-X ™

CAS: 173334-58-2

Aliskiren is a drug that belongs to the group of angiotensin receptor blockers. It is a renin inhibitor that is used for the treatment of hypertension, congestive heart failure, and renal impairment. Aliskiren inhibits the action of angiotensin II by blocking the binding of this hormone to its receptors.

Formula: C₃₀H₅₃N₃O₆•(C₄H₄O₄)₀

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,219.59 g/mol

Ref: 3D-BA164146

Aliskiren hemifumarate

CAS: 173334-58-2

Non-peptide renin inhibitor; anti-hypertensive

Formula: C₃₀H₅₃N₃O₆·C₄H₄O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 1,219.59 g/mol

Ref: 3D-FA17280

ALISKIREN HEMIFUMARATE

CAS: 173334-58-2

Purity: 98%

Molecular weight: 1219.609985

Ref: 10-F813780

Aliskiren Hemifumarate

Controlled Product

CAS: 173334-58-2

Applications: An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.
References Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000), Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002), Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003), Grandman, A.H., et al.: Circulation, 111, 1012 (2005),

Formula: C₃₀H₅₃N₃O₆·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 1219.59

Ref: TR-A536001