CAS 173424-77-6
:Laromustine
Description:
Laromustine, with the CAS number 173424-77-6, is a synthetic alkylating agent primarily investigated for its potential use in cancer therapy, particularly in the treatment of acute myeloid leukemia (AML). It is a prodrug that is converted in the body to its active form, which exerts cytotoxic effects by forming DNA cross-links, ultimately leading to cell death. Laromustine is characterized by its ability to target rapidly dividing cells, a hallmark of many cancer types. Its mechanism of action involves the disruption of DNA replication and transcription, which is critical for cancer cell proliferation. Additionally, Laromustine has been studied for its potential to overcome resistance to other chemotherapeutic agents. The compound is typically administered intravenously and has been evaluated in clinical trials to assess its efficacy and safety profile. As with many chemotherapeutic agents, potential side effects may include myelosuppression, nausea, and increased risk of infections due to its impact on bone marrow function. Overall, Laromustine represents a promising avenue in the ongoing search for effective cancer treatments.
Formula:C6H14ClN3O5S2
InChI:InChI=1S/C6H14ClN3O5S2/c1-8-6(11)10(17(3,14)15)9(5-4-7)16(2,12)13/h4-5H2,1-3H3,(H,8,11)
InChI key:InChIKey=PVCULFYROUOVGJ-UHFFFAOYSA-N
SMILES:N(N(S(C)(=O)=O)CCCl)(S(C)(=O)=O)C(NC)=O
Synonyms:- Laromustine
- 101M
- VNP 40101M
- Cloretazine
- Methanesulfonic acid, 1-(2-chloroethyl)-2-[(methylamino)carbonyl]-2-(methylsulfonyl)hydrazide
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Found 2 products.
Laromustine
CAS:<p>Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.</p>Formula:C6H14ClN3O5S2Purity:≥98%Color and Shape:SolidMolecular weight:307.78
