CAS 173547-45-0

Cyclophosphamide-d4

Description:

Cyclophosphamide-d4 is a deuterated form of cyclophosphamide, a widely used chemotherapeutic agent primarily employed in the treatment of various cancers, including lymphomas and leukemias. The "d4" designation indicates that four hydrogen atoms in the cyclophosphamide molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the substance's utility in pharmacokinetic studies and metabolic research, as deuterated compounds often exhibit altered metabolic pathways and can be tracked more easily in biological systems. Cyclophosphamide itself is an alkylating agent that works by interfering with DNA replication, leading to cell death, particularly in rapidly dividing cells. The presence of deuterium may also influence the compound's solubility, stability, and overall pharmacological properties. Cyclophosphamide-d4 is typically used in research settings rather than clinical applications, providing valuable insights into drug metabolism and the mechanisms of action of cyclophosphamide in cancer therapy.

Formula: C₇H₁₁D₄Cl₂N₂O₂P

InChI: InChI=1/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)/i1D2,4D2

SMILES: C1(C(NP(=O)(N(CCCl)CCCl)OC1)([2H])[2H])([2H])[2H]

Synonyms:

• Cycloblastin-d4
• Cyclostin-d4
• Cytoxan-d4
• Endoxan-d4
• Genoxal-d4
• Hexadrin-d4
• Mitoxan-d4
• N,N-bis(2-chloroethyl)(4,4,5,5-2H4)-1,3,2-oxazaphosphinan-2-amine 2-oxide

Cyclophosphamide-d4

Controlled Product

CAS: 173547-45-0

Applications It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),

Formula: C₇₂H₄H₁₁Cl₂N₂O₂P

Color and Shape: Off-White

Molecular weight: 265.11

Ref: TR-C988582

Cyclophosphamide-d4

CAS: 173547-45-0

Cyclophosphamide-d4 is a deuterated compound of Cyclophosphamide. Cyclophosphamide has a CAS number of 50-18-0. Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.

Formula: C₇H₁₁D₄Cl₂N₂O₂P

Color and Shape: Solid

Molecular weight: 265.11

Ref: TM-TMID-0204

2H-1,3,2-Oxazaphosphorin-4,5-d2-2-amine, N,N-bis(2-chloroethyl)tetrahydro-4,5-d2-, 2-oxide (9CI)

CAS: 173547-45-0

Formula: C₇H₁₁Cl₂D₄N₂O₂P

Color and Shape: Solid

Molecular weight: 265.1106

Ref: IN-DA001YZT