CAS 173937-91-2

Atrasentan

Description:

Atrasentan is a selective endothelin receptor antagonist primarily targeting the endothelin A (ETA) receptor. It is classified as a small molecule and is primarily investigated for its potential therapeutic applications in conditions such as cancer and hypertension. Atrasentan works by inhibiting the action of endothelin-1, a potent vasoconstrictor that plays a significant role in vascular biology and pathophysiology. The compound is known for its ability to reduce blood pressure and improve renal function in certain clinical settings. In terms of its chemical structure, Atrasentan features a complex arrangement that includes various functional groups contributing to its biological activity. The substance is typically administered orally and has undergone various clinical trials to assess its efficacy and safety profile. As with many pharmacological agents, potential side effects may include fluid retention and changes in liver function tests. Overall, Atrasentan represents a targeted approach in the management of diseases associated with endothelin signaling.

Formula: C₂₉H₃₈N₂O₆

InChI: InChI=1S/C29H38N2O6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28H,4-7,14-15,17-19H2,1-3H3,(H,33,34)/t23-,27-,28+/m1/s1

InChI key: InChIKey=MOTJMGVDPWRKOC-QPVYNBJUSA-N

SMILES: C(O)(=O)[C@H]1[C@@H](N(CC(N(CCCC)CCCC)=O)C[C@@H]1C=2C=C3C(=CC2)OCO3)C4=CC=C(OC)C=C4

Synonyms:

• (+)-A 127722
• (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic acid
• (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid
• (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride (1:1)
• 3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-, (2R,3R,4S)-
• 3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-, [2R-(2α,3β,4α)]-
• A 147627
• Abt 627
• Altrasentan

3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-, (2R,3R,4S)-

CAS: 173937-91-2

Formula: C₂₉H₃₈N₂O₆

Purity: %

Color and Shape: Solid

Molecular weight: 510.6218

Ref: IN-DA001ZB3

Atrasentan

CAS: 173937-91-2

Ref: 7W-GK7102

Atrasentan

CAS: 173937-91-2

Atrasentan

Purity: ≥95%

Molecular weight: 510.62g/mol

Ref: 54-BUP01496

Atrasentan

CAS: 173937-91-2

Formula: C₂₉H₃₈N₂O₆

Molecular weight: 510.63

Ref: 4Z-A-399001

Atrasentan

CAS: 173937-91-2

Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.

Formula: C₂₉H₃₈N₂O₆

Purity: 97.65% - 99.08%

Color and Shape: Solid

Molecular weight: 510.62

Ref: TM-TQ0259

Atrasentan

Controlled Product

CAS: 173937-91-2

Applications Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
References Bax, W., et al.: Trends Pharmacol. Sci., 15, 379 (1994); Winn, M., et al.: J. Med. Chem., 39, 1039 (1996); Wu-Wong, J., et al.: J. Pharmacol. Exp. Ther., 281, 791 (1997);

Formula: C₂₉H₃₈N₂O₆

Color and Shape: Off-White

Molecular weight: 510.62

Ref: TR-A793925

Atrasentan

CAS: 173937-91-2

Endothelin receptor antagonist

Formula: C₂₉H₃₈N₂O₆

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 510.62 g/mol

Ref: 3D-FA29947