CAS 174022-42-5

Bevirimat

Description:

Bevirimat is an antiretroviral compound primarily investigated for its potential use in the treatment of HIV. It belongs to a class of drugs known as maturation inhibitors, which work by interfering with the maturation process of the HIV virus, thereby preventing it from becoming infectious. The chemical structure of Bevirimat includes a complex arrangement of carbon, hydrogen, and oxygen atoms, contributing to its unique properties and mechanism of action. It is typically administered orally and has been studied for its efficacy in various clinical settings. Bevirimat's mechanism involves binding to the Gag protein of HIV, which is crucial for the virus's maturation and assembly. While it has shown promise in clinical trials, its use has been limited due to the emergence of resistance and the need for further research to fully understand its long-term efficacy and safety profile. Overall, Bevirimat represents an important area of research in the ongoing effort to develop effective treatments for HIV/AIDS.

Formula: C₃₆H₅₆O₆

InChI: InChI=1S/C36H56O6/c1-21(2)22-12-17-36(30(40)41)19-18-34(8)23(28(22)36)10-11-25-33(7)15-14-26(42-27(37)20-31(3,4)29(38)39)32(5,6)24(33)13-16-35(25,34)9/h22-26,28H,1,10-20H2,2-9H3,(H,38,39)(H,40,41)/t22-,23+,24-,25+,26-,28+,33-,34+,35+,36-/m0/s1

InChI key: InChIKey=YJEJKUQEXFSVCJ-WRFMNRASSA-N

SMILES: C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@H](OC(CC(C(O)=O)(C)C)=O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]

Synonyms:

• (3β)-3-(3-Carboxy-3-methyl-1-oxobutoxy)lup-20(29)-en-28-oic acid
• 3-O-(3′,3′-Dimethylsuccinyl)betulinic acid
• 3beta-(3-Carboxy-3-methylbutanoyloxy)lup-20(29)-en-28-oic acid　　　　　　3β-(3-Carboxy-3-methylbutyryloxy)lup-20(29)-en-28-oic acid　　　　　　O-(3,3-Dimethylsuccinyl)betulinic acid
• Bevirimat
• Bevirimat Dimeglumine
• Fh 11327
• Lup-20(29)-en-28-oic acid, 3-(3-carboxy-3-methyl-1-oxobutoxy)-, (3β)-
• Mp 4326
• O-(3,3-Dimethylsuccinyl)betulinic acid
• Pa-457
• Yk-Fh312
• CS-1322
• PA-457; MPC-4326; FH11327; YK FH312
• MPC-4326
• Bevirimat 174022-42-5
• BVM
• Bevirimat, PA 457, FH 312
• BVM; MPC-4326; PA-457
• Bevirimat, >99%

Lup-20(29)-en-28-oic acid, 3-(3-carboxy-3-methyl-1-oxobutoxy)-, (3β)-

CAS: 174022-42-5

Formula: C₃₆H₅₆O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 584.8262

Ref: IN-DA001ZEC

Bevirimat

CAS: 174022-42-5

Formula: C₃₆H₅₆O₆

Molecular weight: 584.84

Ref: 7W-GY4095

Bevirimat

CAS: 174022-42-5

Bevirimat

Purity: ≥95%

Molecular weight: 584.83g/mol

Ref: 54-BUP04562

Bevirimat

CAS: 174022-42-5

Bevirimat

Formula: C₃₆H₅₆O₆

Purity: 95%~99%

Molecular weight: 584.838

Ref: BP-BP3086

Bevirimat

CAS: 174022-42-5

Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein

Formula: C₃₆H₅₆O₆

Purity: 99.4% - ≥95%

Color and Shape: Solid

Molecular weight: 584.83

Ref: TM-T5782

Bevirimat

CAS: 174022-42-5

Bevirimat is an antiretroviral compound that is derived from a natural source, specifically from the betulinic acid found in certain plant species. This compound functions as a HIV-1 maturation inhibitor by interfering with the Gag protein processing, which is essential for the maturation and release of infectious virions. By preventing the final processing step in the Gag protein, Bevirimat disrupts the formation of the mature capsid core, leading to the production of non-infectious viral particles.

Formula: C₃₆H₅₆O₆

Purity: Min. 95%

Molecular weight: 584.83 g/mol

Ref: 3D-ZGA02242

Bevirimat

CAS: 174022-42-5

Applications Bevirimat is a HIV-1 maturation inhibitor, targetting the Gag CA-SP1 cleavage site. HIV Inhibitor.
References Coric, P. et al.: Eur. J. Med. Chem., 62, 453 (2013); Waki, K. et al.: PLoS Path., 8, e1002997 (2012);

Formula: C₃₆H₅₆O₆

Color and Shape: Neat

Molecular weight: 584.83

Ref: TR-B334700