CAS 174264-50-7

RALOXIFENE 6-GLUCURONIDE

Description:

Raloxifene 6-glucuronide is a metabolite of raloxifene, a selective estrogen receptor modulator (SERM) primarily used in the treatment and prevention of osteoporosis in postmenopausal women. This compound is characterized by its glucuronidation, a process that enhances the solubility and excretion of drugs. Raloxifene 6-glucuronide exhibits similar pharmacological properties to its parent compound, contributing to its efficacy in modulating estrogen receptors, particularly in bone tissue. It is known for its ability to mimic estrogen's beneficial effects on bone density while minimizing risks associated with hormone replacement therapy. The compound is typically studied in the context of pharmacokinetics and metabolism, as its formation and elimination can influence the overall therapeutic outcomes of raloxifene. Additionally, its safety profile and potential interactions with other medications are important considerations in clinical settings. Overall, raloxifene 6-glucuronide plays a significant role in the pharmacological landscape of osteoporosis treatment.

Formula: C₃₄H₃₅NO₁₀S

InChI: InChI=1/C34H35NO10S/c36-21-8-4-20(5-9-21)32-26(27(37)19-6-10-22(11-7-19)43-17-16-35-14-2-1-3-15-35)24-13-12-23(18-25(24)46-32)44-34-30(40)28(38)29(39)31(45-34)33(41)42/h4-13,18,28-31,34,36,38-40H,1-3,14-17H2,(H,41,42)/t28-,29-,30-,31?,34+/m0/s1

Synonyms:

• Raloxifene-D4-6'-Glucuronide
• 2-(4-Hydroxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxybenzoyl]benzo[b]thien-6-yl]-D-glucopyranosiduronicacid
• 2-(4-Hydroxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxybenzoyl]benzo[b]thien-6-yl]-b-D-glucopyranosiduronic Acid
• 2-(4-Hydroxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy-d4-benzoyl]benzo[b]thien-6-yl]-b-D-glucopyranosiduronic Acid
• Ralaxifene6'-glucuronide
• (2-(4-Hydroxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy-D4-benzoyl]benzo[b]thien-6-yl]-D-glucopyranosiduronic acid)

Raloxifene-6-Glucuronide Lithium Salt

CAS: 174264-50-7

Formula: C₃₄H₃₄NO₁₀S·Li

Color and Shape: Yellow Solid

Molecular weight: 648.70 6.94

Ref: 4Z-R-016

Raloxifene-d4-6-Glucuronide Lithium Salt

CAS: 174264-50-7

Formula: C₃₄H₃₀D₄NO₁₀S·Li

Color and Shape: Deep Yellow Solid

Molecular weight: 652.73 6.94

Ref: 4Z-R-015

Raloxifene 6-glucuronide

CAS: 174264-50-7

Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8.

Formula: C₃₄H₃₅NO₁₀S

Purity: 98%

Color and Shape: Solid

Molecular weight: 649.71

Ref: TM-T12688

Raloxifene-6-Glucuronide

CAS: 174264-50-7

Formula: C₃₄H₃₅NO₁₀S

Color and Shape: Pale Yellow Solid

Molecular weight: 649.71

Ref: 4Z-R-013

Raloxifene-6-D-glucuronide lithium salt

CAS: 174264-50-7

Ref: 7W-GC1964

Raloxifene 6-O-β-D-glucuronide

CAS: 174264-50-7

Raloxifene 6-O-β-D-glucuronide

Molecular weight: 649.7074g/mol

Ref: 54-BICL2521

Raloxifene 6-Glucuronide

Controlled Product

CAS: 174264-50-7

Applications A metabolite of Raloxifene, a nonsteroidal estrogen receptor mixed agonist/antagonist.
References Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997), Jeong, E., et al.: Drug Metab. Dispos., 33, 785 (2005), Trontelj, J., et al.: Pharmacol. Res., 52, 334 (2005), Oswald, S., et al.: Clin. Pharmacol. Ther., 79 206 (2006),

Formula: C₃₄H₃₅NO₁₀S

Color and Shape: Light Yellow To Yellow

Molecular weight: 649.71

Ref: TR-R100025

Raloxifene 6-D-glucuronide

CAS: 174264-50-7

Raloxifene 6-D-glucuronide is a synthetic compound that consists of the sugar raloxifene and the sugar glucuronic acid. It is a complex carbohydrate with a molecular weight of 569. Raloxifene 6-D-glucuronide is soluble in water and insoluble in most organic solvents. The compound has been modified by fluorination, which increases its stability in water, and by click modification. This compound has been shown to inhibit the activity of bacterial enzymes that are responsible for the synthesis of saccharides, such as oligosaccharides and polysaccharides.

Formula: C₃₄H₃₅NO₁₀S

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 649.71 g/mol

Ref: 3D-MR07278

Raloxifene-6-D-glucuronide lithium salt

CAS: 174264-50-7

Raloxifene-6-D-glucuronide lithium salt is a custom synthesis of a complex carbohydrate. It is an oligosaccharide that has been modified by methylation and glycosylation. The modification of the saccharide with click chemistry has provided a high purity product. This compound has been fluorinated to provide an organic molecule with a pharmaceutical grade purity.

Formula: C₃₄H₃₄NO₁₀S·Li

Purity: Min. 95%

Molecular weight: 655.64 g/mol

Ref: 3D-MR09927

Raloxifene 6-β-D-Glucuronide Lithium Salt

Controlled Product

CAS: 174264-50-7

Stability Hygroscopic
Applications Raloxifene 6-Glucuronide Lithium Salt is A metabolite of Raloxifene (R100000), a nonsteroidal estrogen receptor mixed agonist/antagonist.
References Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997); Jeong, E., et al.: Drug Metab. Dispos., 33, 785 (2005); Trontelj, J., et al.: Pharmacol. Res., 52, 334 (2005); Oswald, S., et al.: Clin. Pharmacol. Ther., 79 206 (2006)

Formula: C₃₄H₃₄LiNO₁₀S

Color and Shape: Neat

Molecular weight: 655.64

Ref: TR-R100026

Raloxifene-d4 6-Glucuronide

Controlled Product

CAS: 174264-50-7

Formula: C₃₄H₃₁D₄NO₁₀S

Color and Shape: Yellow To Dark Yellow

Molecular weight: 653.73

Ref: TR-R100027

Raloxifene 6-glucuronide

CAS: 174264-50-7

Formula: C₃₄H₃₅NO₁₀S

Molecular weight: 649.71

Ref: ST-EA-CP-R2034