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CAS 1744-64-5

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(6α,11β,16α)-6-Chloro-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Description:
The chemical substance known as "(6α,11β,16α)-6-Chloro-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione," with the CAS number 1744-64-5, is a synthetic corticosteroid. It exhibits anti-inflammatory and immunosuppressive properties, making it useful in various medical applications, particularly in the treatment of conditions such as asthma, allergies, and autoimmune disorders. The structure of this compound features a steroid backbone, characterized by a fused four-ring system, which is typical of corticosteroids. The presence of halogen atoms, specifically chlorine and fluorine, contributes to its biological activity and potency. Additionally, the hydroxyl groups in its structure enhance its solubility and reactivity, influencing its pharmacokinetics and pharmacodynamics. As with many corticosteroids, it is essential to monitor for potential side effects, including hormonal imbalances and metabolic changes, during therapeutic use. Overall, this compound exemplifies the complexity and utility of synthetic steroids in modern medicine.
Formula:C22H28ClFO5
InChI:InChI=1S/C22H28ClFO5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key:InChIKey=CDGJSUBGFOVZMH-GQKYHHCASA-N
SMILES:F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(C[C@H](Cl)C=4[C@]2(C)C=CC(=O)C4)[H]
Synonyms:
  • (6α,11β,16α)-6-Chloro-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 6α-chloro-9-fluoro-11β,17,21-trihydroxy-16α-methyl-
  • Pregna-1,4-diene-3,20-dione, 6-chloro-9-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
  • 6α-Chlorodexamethasone
  • (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6-chloro-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • -Chlorodexamethasone
  • Flumethasone Impurity 2
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