CAS 174423-36-0

Cyclo[2,3-didehydroalanyl-N-methylglycyl-2-[(1R)-1-aminoethyl]-4-thiazolecarbonyl-L-tryptophyl-4-methoxy-L-tryptophylglycyl-(2R)-2-aminobutanoyl]

Description:

Cyclo[2,3-didehydroalanyl-N-methylglycyl-2-[(1R)-1-aminoethyl]-4-thiazolecarbonyl-L-tryptophyl-4-methoxy-L-tryptophylglycyl-(2R)-2-aminobutanoyl] is a complex cyclic peptide with a unique structure that incorporates various amino acids and functional groups. Its molecular architecture includes a thiazole carbonyl moiety, which contributes to its potential biological activity. The presence of multiple chiral centers indicates that this compound may exhibit stereochemical specificity, influencing its interactions with biological targets. The incorporation of tryptophan residues suggests potential roles in receptor binding or enzyme inhibition, while the N-methyl and aminoethyl substituents may enhance its pharmacological properties. This compound is likely to be of interest in medicinal chemistry and drug design, particularly for its potential therapeutic applications. However, detailed studies on its solubility, stability, and biological activity would be necessary to fully understand its characteristics and potential uses in pharmaceutical contexts.

Formula: C₄₁H₄₆N₁₀O₈S

Synonyms:

• Argyrin B
• Cyclo[2,3-didehydroalanyl-N-methylglycyl-2-[(1R)-1-aminoethyl]-4-thiazolecarbonyl-L-tryptophyl-4-methoxy-L-tryptophylglycyl-(2R)-2-aminobutanoyl]

Argyrin B

CAS: 174423-36-0

Argyrin B is a naturally occurring cyclic peptide that acts as a reversible non-competitive inhibitor of the immunoproteasome. It exhibits higher inhibitory selectivity for the β5i and β1i sites of the immunoproteasome compared to the β5c and β1c sites of the constitutive proteasome, being nearly 20 times more selective for β1i than for its homolog β1c. Additionally, Argyrin B possesses antibacterial properties.

Formula: C₄₁H₄₆N₁₀O₈S

Color and Shape: Solid

Molecular weight: 838.931

Ref: TM-TN9039