CAS 174569-25-6

Methoxypolyethylene glycol-succinimidyl propionate

Description:

Methoxypolyethylene glycol-succinimidyl propionate (MPEG-SP) is a bioconjugation reagent commonly used in biochemistry and pharmaceutical applications. It features a methoxy-terminated polyethylene glycol (PEG) chain, which enhances solubility and biocompatibility, making it suitable for drug delivery systems. The succinimidyl group allows for the formation of stable amide bonds with primary amines, facilitating the conjugation of proteins, peptides, or other biomolecules. MPEG-SP is characterized by its ability to improve the pharmacokinetic properties of conjugated molecules, such as increased circulation time and reduced immunogenicity. Additionally, the PEG component can help to reduce protein aggregation and enhance the stability of the conjugated product. This compound is typically used in the development of therapeutics, diagnostics, and in the modification of biomaterials. Its versatility and effectiveness in bioconjugation make it a valuable tool in the fields of drug development and molecular biology.

Formula: C₈₀H₁₅₅NO₄₁

InChI: InChI=1S/C10H15NO6/c1-15-6-7-16-5-4-10(14)17-11-8(12)2-3-9(11)13/h2-7H2,1H3

InChI key: InChIKey=IMSXKORGOVQCNT-UHFFFAOYSA-N

SMILES: O(C(CCOCCOC)=O)N1C(=O)CCC1=O

Synonyms:

• mPEG-SPA
• Methoxypolyethylene glycol-succinimidyl propionate
• O-[2-(N-Succinimidyloxycarbonyl)ethyl]-O′-methylpolyethylene glycol
• Poly(oxy-1,2-ethanediyl), α-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-ω-methoxy-
• SP-mPEG
• alpha-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-omega-methoxypoly(oxy-1,2-ethanediyl)
• m-PEGn-NHS ester
• Methyl-PEGn-NHS (n=12,13,24)
• MPEGn-SPA 2K, 5K, 10K, 20K
• m-PEG17-NHS ester

Methoxy-PEG-(succinimidyl propionate)

CAS: 174569-25-6

Formula: C₁₀H₁₅N₂O₆

Color and Shape: Solid

Molecular weight: 259.2359

Ref: IN-DA001ZRW

m-PEG13-NHS ester

CAS: 174569-25-6

m-PEG13-NHS ester

Molecular weight: 729.81g/mol

Ref: 54-BIPG1629

mPEG11-NHS

CAS: 174569-25-6

mPEG11-NHS is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. mPEG11-NHS is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Formula: C₃₀H₅₅NO₁₆

Purity: Min. 95%

Molecular weight: 685.75 g/mol

Ref: 3D-FM72947