CAS 174569-25-6: Methoxypolyethylene glycol-succinimidyl propionate

Description: Methoxypolyethylene glycol-succinimidyl propionate (MPEG-SP) is a bioconjugation reagent commonly used in biochemistry and pharmaceutical applications. It features a methoxy-terminated polyethylene glycol (PEG) chain, which enhances solubility and biocompatibility, making it suitable for drug delivery systems. The succinimidyl group allows for the formation of stable amide bonds with primary amines, facilitating the conjugation of proteins, peptides, or other biomolecules. MPEG-SP is characterized by its ability to improve the pharmacokinetic properties of conjugated molecules, such as increased circulation time and reduced immunogenicity. Additionally, the PEG component can help to reduce protein aggregation and enhance the stability of the conjugated product. This compound is typically used in the development of therapeutics, diagnostics, and in the modification of biomaterials. Its versatility and effectiveness in bioconjugation make it a valuable tool in the fields of drug development and molecular biology.

Formula: (C₂H₄O)nC₈H₁₁NO₅

InChI: InChI=1S/C10H15NO6/c1-15-6-7-16-5-4-10(14)17-11-8(12)2-3-9(11)13/h2-7H2,1H3

InChI key: InChIKey=IMSXKORGOVQCNT-UHFFFAOYSA-N

SMILES: O=C(ON1C(=O)CCC1=O)CCOCCOC

Synonyms:

• mPEG-SPA
• Methoxypolyethylene glycol-succinimidyl propionate
• O-[2-(N-Succinimidyloxycarbonyl)ethyl]-O′-methylpolyethylene glycol
• Poly(oxy-1,2-ethanediyl), α-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-ω-methoxy-
• SP-mPEG

Poly(oxy-1,2-ethanediyl), α-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-ω-methoxy-

CAS: 174569-25-6

• Formula: C₁₀H₁₅N₂O₆
• Color and Shape: Solid
• Molecular weight: 259.2359

mPEG11-NHS

CAS: 174569-25-6

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• Formula: C₃₀H₅₅NO₁₆
• Purity: Min. 95%
• Molecular weight: 685.75 g/mol