CAS 17466-45-4

phalloidin from amanita phalloides

Description:

Phalloidin is a cyclic peptide derived from the deadly mushroom Amanita phalloides, commonly known as the death cap mushroom. It is classified as a potent toxin and is known for its ability to bind to and stabilize actin filaments, which disrupts normal cellular functions. Phalloidin is characterized by its high affinity for F-actin, leading to the inhibition of actin dynamics, which is crucial for various cellular processes, including cell motility and division. The compound is not only toxic but also serves as a valuable tool in biological research, particularly in the study of the cytoskeleton and cell structure. Phalloidin is often conjugated with fluorescent dyes for visualization of actin filaments in microscopy. Its molecular structure includes several amino acids, contributing to its stability and binding properties. Due to its toxicity, phalloidin must be handled with care in laboratory settings, and its use is typically restricted to controlled environments where appropriate safety measures are in place.

Formula: C₃₅H₄₈N₈O₁₁S

InChI: InChI=1/C35H48N8O11S/c1-15-27(47)38-22-10-20-19-7-5-6-8-21(19)41-33(20)55-13-24(34(53)43-12-18(46)9-25(43)31(51)37-15)40-32(52)26(17(3)45)42-28(48)16(2)36-30(50)23(39-29(22)49)11-35(4,54)14-44/h5-8,15-18,22-26,41,44-46,54H,9-14H2,1-4H3,(H,36,50)(H,37,51)(H,38,47)(H,39,49)(H,40,52)(H,42,48)/t15-,16-,17-,18-,22-,23-,24-,25-,26+,35+/m0/s1

Synonyms:

• Phalloidin, Amanita phalloides
• Phalloidin
• 29-(2,3-dihydroxy-2-methylpropyl)-2-hydroxy-23-(1-hydroxyethyl)-6,26-dimethyl-1,2,3,3a,5,6,8,9,10,15-decahydro-17H-18,9-(epiminoethanoiminoethanoiminoethanoiminomethano)pyrrolo[1',2':5,6][1,5,8,11]thiatriazacyclopentadecino[15,14-b]indole-4,7,19,22,25,28,31(18H)-heptone
• (2S,3aS,6S,9S,18R,23R,26S,29S)-29-[(2R)-2,3-dihydroxy-2-methylpropyl]-2-hydroxy-23-[(1S)-1-hydroxyethyl]-6,26-dimethyl-1,2,3,3a,5,6,8,9,10,15-decahydro-17H-18,9-(epiminoethanoiminoethanoiminoethanoiminomethano)pyrrolo[1',2':5,6][1,5,8,11]thiatriazacyclopentadecino[15,14-b]indole-4,7,19,22,25,28,31(18H)-heptone

Phalloidin

CAS: 17466-45-4

A bicyclic 7 amino acid peptide toxin originally isolated from the poisonous mushroom Amanita phalloides. Phalloidin binds specifically to the interface between F-actin subunits.

Formula: C₃₅H₄₈N₈O₁₁S

Purity: 96.4%

Color and Shape: White Lyophilisate

Molecular weight: 788.87

Ref: 01-4095642

Phalloidin

CAS: 17466-45-4

Formula: C₃₅H₄₈N₈O₁₁S

Purity: ≥ 90.0%

Color and Shape: White powder

Molecular weight: 788.87

Ref: 7W-GK5528

Phalloidin

CAS: 17466-45-4

Phalloidin is a bicyclic heptapeptide found in Phaeodactylus, which interferes with cell motility and growth, and can be used to label cerebral blood vessels.

Formula: C₃₅H₄₈N₈O₁₁S

Purity: 98%

Color and Shape: White Powder

Molecular weight: 788.87

Ref: TM-T19512

Phalloidin

CAS: 17466-45-4

Phalloidin

Formula: C₃₅H₄₈N₈O₁₁S

Purity: >90% (Typical Value in Batch COA)

Color and Shape: White Solid

Molecular weight: 788.86762g/mol

Ref: 54-BIP0842

Phalloidine (>80%)

Controlled Product

CAS: 17466-45-4

Applications Phalloidin is an F-actin stabilizing toxin and aids cytoskeletal deorganization in WPMY-1 cells. Phalloidin belongs to a class of toxins called phallotoxins, which are found in the death cap mushroom
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, Y., et al.: Br. J. Pharmacol., 173, 3342-3358 (2016);

Formula: C₃₅H₄₈N₈O₁₁S

Purity: >80%

Color and Shape: Neat

Molecular weight: 788.87

Ref: TR-P294523