CAS 175203-08-4

4-(4-Chlorophenyl)-2(1H)-pyrimidinethione

Description:

4-(4-Chlorophenyl)-2(1H)-pyrimidinethione, identified by its CAS number 175203-08-4, is a chemical compound that belongs to the class of pyrimidinethiones. This substance features a pyrimidine ring substituted with a chlorophenyl group and a thioketone functional group, which contributes to its unique chemical properties. The presence of the chlorophenyl moiety enhances its lipophilicity and may influence its biological activity. Typically, compounds of this nature exhibit potential applications in pharmaceuticals, particularly in the development of antimicrobial or anticancer agents, due to their ability to interact with biological targets. The compound's structure suggests it may participate in various chemical reactions, including nucleophilic substitutions and electrophilic additions, owing to the reactivity of the thioketone group. Additionally, its solubility and stability can vary depending on the solvent and environmental conditions, which are important factors to consider in practical applications. Overall, 4-(4-Chlorophenyl)-2(1H)-pyrimidinethione is a compound of interest in medicinal chemistry and related fields.

Formula: C₁₀H₇ClN₂S

InChI: InChI=1/C10H7ClN2S/c11-8-3-1-7(2-4-8)9-5-6-12-10(14)13-9/h1-6H,(H,12,13,14)

InChI key: InChIKey=TWKIWOOKHPWUIM-UHFFFAOYSA-N

SMILES: S=C1NC(=CC=N1)C2=CC=C(Cl)C=C2

Synonyms:

• 2(1H)-Pyrimidinethione, 4-(4-chlorophenyl)-
• 4-(4-Chlorophenyl)-2(1H)-pyrimidinethione
• 4-(4-Chlorophenyl)-2-mercaptopyrimidine
• 6-(4-chlorophenyl)pyrimidine-2(1H)-thione
• 4-(4-Chlorophenyl)pyrimidine-2-thiol
• AKOS B020820
• ART-CHEM-BB B020820
• SALOR-INT L481459-1EA
• BUTTPARK 25\04-71

2(1H)-Pyrimidinethione, 4-(4-chlorophenyl)-

CAS: 175203-08-4

Formula: C₁₀H₇ClN₂S

Purity: 95%

Color and Shape: Solid

Molecular weight: 222.6940

Ref: IN-DA0020IT

4-(4-Chlorophenyl)pyrimidine-2-thiol

CAS: 175203-08-4

4-(4-Chlorophenyl)pyrimidine-2-thiol

Purity: ≥95%

Molecular weight: 222.69g/mol

Ref: 54-OR4211

4-(4-CHLORO-PHENYL)-PYRIMIDINE-2-THIOL

CAS: 175203-08-4

Formula: C₁₀H₇ClN₂S

Purity: 95%

Molecular weight: 222.69

Ref: 10-F300956

4-(4-Chlorophenyl)pyrimidine-2-thiol

CAS: 175203-08-4

4-(4-Chlorophenyl)pyrimidine-2-thiol is an anti-cancer drug that is used in the treatment of ovarian cancer. It has been shown to be effective against cancer cells by interfering with the DNA replication process. 4-(4-Chlorophenyl)pyrimidine-2-thiol binds at the active site of topoisomerase II, which is involved in the process of transcription and replication. This drug also has been shown to induce apoptosis in fibroblast cells by inhibiting DNA synthesis and protein synthesis. 4-(4-Chlorophenyl)pyrimidine-2-thiol has a molecular weight of 181.24 g/mol and is soluble in water, methanol, and ethanol. The colorimetric assay for this compound has a detection limit of 1 µg/mL.

Purity: Min. 95%

Ref: 3D-NC44282