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CAS 17528-72-2

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Tetrahydrobiopterin

Description:
Tetrahydrobiopterin (BH4) is a naturally occurring pteridine derivative that serves as a crucial cofactor in the biosynthesis of several neurotransmitters, including serotonin, dopamine, and norepinephrine. It plays a significant role in the hydroxylation of aromatic amino acids, particularly phenylalanine, into tyrosine. BH4 is a water-soluble compound, characterized by its light-sensitive nature, which necessitates careful handling and storage to maintain its stability. The substance is involved in various metabolic pathways and is essential for normal neurological function. Deficiencies in tetrahydrobiopterin can lead to metabolic disorders, such as phenylketonuria (PKU) and other neurotransmitter-related conditions. In addition to its biological significance, BH4 has been studied for its potential therapeutic applications, including its role in cardiovascular health and as a treatment for certain neurological disorders. Its chemical structure features a pteridine ring system with multiple hydroxyl groups, contributing to its reactivity and function as a cofactor in enzymatic reactions.
Formula:C9H15N5O3
InChI:InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)
InChI key:InChIKey=FNKQXYHWGSIFBK-UHFFFAOYSA-N
SMILES:O=C1C2=C(NCC(C(C(C)O)O)N2)NC(N)=N1
Synonyms:
  • 5,6,7,8-Tetrahydrobiopterin
  • Tetrahydrobiopterin
  • 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinone
  • 4(3H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-
  • 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-
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