CAS 175556-12-4

Ro 46-8443

Description:

Ro 46-8443, with the CAS number 175556-12-4, is a chemical compound that belongs to the class of selective serotonin reuptake inhibitors (SSRIs). It is primarily researched for its potential applications in treating various psychiatric disorders, particularly depression and anxiety. The compound exhibits a high affinity for serotonin transporters, which facilitates the modulation of serotonin levels in the brain, thereby influencing mood and emotional regulation. Ro 46-8443 is characterized by its specific molecular structure, which contributes to its pharmacological properties. Additionally, it has been studied for its effects on neurotransmitter systems beyond serotonin, potentially impacting dopamine and norepinephrine pathways. As with many compounds in this class, the safety profile, side effects, and long-term efficacy are critical areas of ongoing research. Overall, Ro 46-8443 represents a significant interest in the field of psychopharmacology, with the potential to contribute to therapeutic strategies for mood disorders.

Formula: C₃₁H₃₅N₃O₈S

Synonyms:

• (R)-N-[6-(2,3-Dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)benzenesulfonamide
• RO46-8443, CID 5312146
• Ro 46-8443
• Benzenesulfonamide, N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)-
• (R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
• 4-TERT-BUTYL-N-[6-[(2R)-2,3-DIHYDROXYPROPOXY]-5-(2-METHOXYPHENOXY)-2-(4-METHOXYPHENYL)PYRIMIDIN-4-YL]BENZENESULFONAMIDE
• Inhibitor,RO 468443,Ro 46-8443,selective,ETB,normotensive,RO 46 8443,inhibit,Endothelin Receptor,hypertensive rats,non-peptide

RO 46-8443

CAS: 175556-12-4

Formula: C₃₁H₃₅N₃O₈S

Purity: 99%

Molecular weight: 609.6899

Ref: IN-DA00AMGV

RO 46-8443

CAS: 175556-12-4

RO 46-8443

Purity: ≥98%

Molecular weight: 609.69g/mol

Ref: 54-BUP02749

RO 46-8443

CAS: 175556-12-4

RO 46-8443: First non-peptide ETB receptor antagonist, >2000-fold ETB selectivity in binding and function.

Formula: C₃₁H₃₅N₃O₈S

Purity: 98.77% - 99.77%

Color and Shape: Solid

Molecular weight: 609.69

Ref: TM-T3474

(R)-4-(TERT-BUTYL)-N-(6-(2,3-DIHYDROXYPROPOXY)-5-(2-METHOXYPHENOXY)-2-(4-METHOXYPHENYL)PYRIMIDIN-4-YL)BENZENESULFONAMIDE

CAS: 175556-12-4

Purity: 95%

Molecular weight: 609.6900024414062

Ref: 10-F806263

(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide

CAS: 175556-12-4

(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide is a non-peptide antagonist of endothelin A (ET A ) and endothelin B (ET B ). It has been shown to have a high selectivity for ET A over ET B , with potency at concentrations of 1 nM for ET A and 100 nM for ET B . This compound has been shown to inhibit the release of vasoconstrictive endothelin from cultured human endothelial cells. The inhibition is concentration dependent, with shifts in the concentration-response curves being observed as low as 10 μM. The inhibition of release was characterised by clarifying the mechanism involved.

Formula: C₃₁H₃₅N₃O₈S

Purity: Min. 95%

Molecular weight: 609.7 g/mol

Ref: 3D-AHA55612