CAS 17560-51-9
:Metolazone
Description:
Metolazone, with the CAS number 17560-51-9, is a thiazide-like diuretic medication primarily used to treat hypertension and edema associated with heart failure or renal disorders. It functions by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased urine output. Metolazone is characterized by its chemical formula C16H18ClN3O3S and a molecular weight of approximately 365.85 g/mol. The compound typically appears as a white to off-white crystalline powder, which is slightly soluble in water and more soluble in organic solvents. Its mechanism of action involves the inhibition of the Na+/Cl- co-transporter, which results in enhanced excretion of sodium and chloride ions, thereby reducing fluid retention. Metolazone is often used in combination with other diuretics for synergistic effects, particularly in patients with resistant hypertension. As with any medication, it is important to monitor for potential side effects, including electrolyte imbalances and dehydration.
Formula:C16H16ClN3O3S
InChI:InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
InChI key:InChIKey=AQCHWTWZEMGIFD-UHFFFAOYSA-N
SMILES:O=C1C=2C(=CC(Cl)=C(S(N)(=O)=O)C2)NC(C)N1C3=C(C)C=CC=C3
Synonyms:- 2-Methyl-3-(o-tolyl)-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
- 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-
- 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
- Diulo
- Metazoline
- Metenix
- Metolazon
- Metolazona
- Metolazone
- Metozalone
- Mykrox
- Normelan
- Oldren
- Sr 720-22
- Xuret
- Zaroxolyn
- 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-
- 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
- See more synonyms
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Found 13 products.
Metolazone
CAS:Formula:C16H16ClN3O3SPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:365.83METOLAZONE CRS
CAS:<p>METOLAZONE CRS</p>Formula:C16H16ClN3O3SColor and Shape:Crystalline Powder. White. Light Yellow. Powder.Molecular weight:365.8345METOLAZONE FOR SYSTEM SUITABILITY CRS
CAS:<p>METOLAZONE FOR SYSTEM SUITABILITY CRS</p>Formula:C16H16ClN3O3SColor and Shape:Powder.Molecular weight:365.8345Metolazone
CAS:Sulfonamides used as drugsFormula:C16H16ClN3O3SColor and Shape:White PowderMolecular weight:365.84 g/molMetolazone
CAS:<p>Metolazone (SR-720-22) is a quinazoline-sulfonamide derived diuretic that inhibits sodium chloride symporters.</p>Formula:C16H16ClN3O3SPurity:98.14% - 98.5%Color and Shape:Crystals From Ethanol SolidMolecular weight:365.83Metolazone
CAS:Formula:C16H16ClN3O3SPurity:97.0 - 102.0 %Color and Shape:White to off-white crystalline powderMolecular weight:365.83Metolazone
CAS:Controlled Product<p>Diuretic; inhibits function of the sodium-chloride symporter</p>Formula:C16H16ClN3O3SPurity:Min. 95%Color and Shape:White PowderMolecular weight:365.84 g/molMetolazone
CAS:Controlled Product<p>Applications A diruetic. An antihypertensive.<br>References Curry, C.L., et al.: Clin. Ther., 9, 47 (1986), Kiyingi, A., et al.: Lancet, 335, 29 (1990)<br></p>Formula:C16H16ClN3O3SColor and Shape:NeatMolecular weight:365.83Metolazone-d7
CAS:Controlled Product<p>Applications Metolazone-d7, is the labeled analogue of Metolazone (M338750), which is a diruetic and an antihypertensive.<br>References Curry, C.L., et al.: Clin. Ther., 9, 47 (1986), Kiyingi, A., et al.: Lancet, 335, 29 (1990)<br></p>Formula:C16H9D7ClN3O3SColor and Shape:NeatMolecular weight:372.886-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-
CAS:Formula:C16H16ClN3O3SPurity:98%Color and Shape:SolidMolecular weight:365.8345
