CAS 175865-59-5
:Valganciclovir hydrochloride
Description:
Valganciclovir hydrochloride is an antiviral medication primarily used in the treatment and prevention of cytomegalovirus (CMV) infections, particularly in immunocompromised patients, such as those undergoing organ transplantation or with HIV/AIDS. It is an ester prodrug of ganciclovir, which means it is converted into its active form in the body. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Valganciclovir hydrochloride has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. The drug works by inhibiting viral DNA synthesis, thereby preventing the replication of the virus. Its pharmacokinetics are characterized by a relatively high bioavailability compared to ganciclovir, allowing for effective dosing regimens. However, it may cause side effects, including hematological toxicity, and requires careful monitoring during treatment. Overall, Valganciclovir hydrochloride is a critical therapeutic agent in managing CMV-related diseases.
Formula:C14H22N6O5·ClH
InChI:InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1
InChI key:InChIKey=ZORWARFPXPVJLW-MTFPJWTKSA-N
SMILES:C(OC(COC([C@H](C(C)C)N)=O)CO)N1C2=C(N=C1)C(=O)N=C(N)N2.Cl
Synonyms:- 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate hydrochloride (1:1)
- <span class="text-smallcaps">L</span>-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
- <span class="text-smallcaps">L</span>-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride
- L-Valine, 2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy]-3-Hydroxypropyl Ester, Monohydrochloride
- L-Valine,2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy]-3-Hydroxypropylester,Monohydrochloride
- Ro 107-9070/194
- Rs 079070-194
- Valcyte
- Valganciclovir Hcl
- L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
- Valganciclovir hydrochloride
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Found 17 products.
Valganciclovir Hydrochloride
CAS:Formula:C14H22N6O5·HClPurity:>98.0%(T)Color and Shape:White to Almost white powder to crystalMolecular weight:390.83Valganciclovir Hydrochloride
CAS:Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormula:C14H22N6O5·HClColor and Shape:White Off-White PowderMolecular weight:354.16517Valganciclovir hydrochloride
CAS:Valganciclovir HCl is a prodrug of ganciclovir, an antiviral nucleoside analog; it inhibits viral DNA replication.Formula:C14H23ClN6O5Purity:98.55% - 99.32%Color and Shape:White Crystalline SolidMolecular weight:390.82Ref: TM-T1533
10mg35.00€25mg59.00€50mg87.00€100mg137.00€200mg188.00€500mg329.00€1mL*10mM (DMSO)38.00€L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
CAS:Formula:C14H23ClN6O5Purity:98%Color and Shape:SolidMolecular weight:390.8226(2S)-2-((2-Amino-6-Oxo-1H-Purin-9(6H)-Yl)Methoxy)-3-Hydroxypropyl2-Amino-3-MethylbutanoateHydrochloride
CAS:(2S)-2-((2-Amino-6-Oxo-1H-Purin-9(6H)-Yl)Methoxy)-3-Hydroxypropyl2-Amino-3-MethylbutanoateHydrochloridePurity:98%Molecular weight:390.82g/molValganciclovir-d5 (Mixture of Diastereomers)
CAS:Formula:C14H17D5N6O5Color and Shape:White To Off-White SolidMolecular weight:359.40Valganciclovir HCl (Mixture of Diastereomers)
CAS:Formula:C14H22N6O5·HClColor and Shape:White To Off-White SolidMolecular weight:354.37 36.46Valganciclovir hydrochloride
CAS:Formula:C14H22N6O5·HCl·xH2OPurity:(HPLC) 97.0 - 102 %Color and Shape:White to off-white powderMolecular weight:390.82 (anhydrous)Valganciclovir hydrochloride
CAS:Formula:C14H23ClN6O5Purity:99.0%Color and Shape:SolidMolecular weight:390.83Valganciclovir-d5 Hydrochloride
CAS:Controlled ProductFormula:C14H18D5ClN6O5Purity:>90%Color and Shape:NeatMolecular weight:395.85Valganciclovir Hydrochloride
CAS:Controlled ProductStability Hygroscopic
Applications A pro-drug of Ganciclovir. Used in treatment of retro-virus.
References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),Formula:C14H22N6O5·ClHColor and Shape:White To Off-WhiteMolecular weight:390.82Valganciclovir hydrochloride
CAS:Valganciclovir hydrochloride is a prodrug of ganciclovir. It is an antiviral drug used for the treatment and prevention of cytomegalovirus (CMV) infections. Valganciclovir hydrochloride is a prodrug of ganciclovir, which is converted to the active form in humans by esterases in the liver. Valganciclovir hydrochloride has been shown to be effective against CMV and other herpesviruses, such as herpes zoster virus, varicella-zoster virus, and Epstein-Barr virus. It has minimal toxicity and does not cause bone marrow suppression or organ damage at low doses. Valganciclovir hydrochloride also has a matrix effect that reduces the bioavailability of other drugs taken concurrently with it.
Formula:C14H22N6O5•HClPurity:Min. 95%Color and Shape:White PowderMolecular weight:390.82 g/mol
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