CAS 175865-59-5: Valganciclovir hydrochloride
Description:Valganciclovir hydrochloride is an antiviral medication primarily used in the treatment and prevention of cytomegalovirus (CMV) infections, particularly in immunocompromised patients, such as those undergoing organ transplantation or with HIV/AIDS. It is an ester prodrug of ganciclovir, which means it is converted into its active form in the body. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Valganciclovir hydrochloride has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. The drug works by inhibiting viral DNA synthesis, thereby preventing the replication of the virus. Its pharmacokinetics are characterized by a relatively high bioavailability compared to ganciclovir, allowing for effective dosing regimens. However, it may cause side effects, including hematological toxicity, and requires careful monitoring during treatment. Overall, Valganciclovir hydrochloride is a critical therapeutic agent in managing CMV-related diseases.
Formula:C14H22N6O5·ClH
InChI:InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1
InChI key:InChIKey=ZORWARFPXPVJLW-MTFPJWTKSA-N
SMILES:Cl.O=C1N=C(N)NC2=C1N=CN2COC(CO)COC(=O)C(N)C(C)C
- Synonyms:
- 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate hydrochloride (1:1)
- <span class="text-smallcaps">L</span>-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
- <span class="text-smallcaps">L</span>-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride
- L-Valine, 2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy]-3-Hydroxypropyl Ester, Monohydrochloride
- L-Valine,2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy]-3-Hydroxypropylester,Monohydrochloride
- Ro 107-9070/194
- Rs 079070-194
- Valcyte
- Valganciclovir Hcl
- L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
- See more synonyms
- Valganciclovir hydrochloride