CAS 175865-59-5

Valganciclovir hydrochloride

Description:

Valganciclovir hydrochloride is an antiviral medication primarily used in the treatment and prevention of cytomegalovirus (CMV) infections, particularly in immunocompromised patients, such as those undergoing organ transplantation or with HIV/AIDS. It is an ester prodrug of ganciclovir, which means it is converted into its active form in the body. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Valganciclovir hydrochloride has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. The drug works by inhibiting viral DNA synthesis, thereby preventing the replication of the virus. Its pharmacokinetics are characterized by a relatively high bioavailability compared to ganciclovir, allowing for effective dosing regimens. However, it may cause side effects, including hematological toxicity, and requires careful monitoring during treatment. Overall, Valganciclovir hydrochloride is a critical therapeutic agent in managing CMV-related diseases.

Formula: C₁₄H₂₂N₆O₅·ClH

InChI: InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1

InChI key: InChIKey=ZORWARFPXPVJLW-MTFPJWTKSA-N

SMILES: C(OC(COC([C@H](C(C)C)N)=O)CO)N1C2=C(N=C1)C(=O)N=C(N)N2.Cl

Synonyms:

• 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate hydrochloride (1:1)
• <span class="text-smallcaps">L</span>-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
• <span class="text-smallcaps">L</span>-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride
• L-Valine, 2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy]-3-Hydroxypropyl Ester, Monohydrochloride
• L-Valine,2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy]-3-Hydroxypropylester,Monohydrochloride
• Ro 107-9070/194
• Rs 079070-194
• Valcyte
• Valganciclovir Hcl
• L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
• Valganciclovir hydrochloride

Valganciclovir Hydrochloride

CAS: 175865-59-5

Formula: C₁₄H₂₂N₆O₅·HCl

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 390.83

Ref: 3B-V0158

VALGANCICLOVIR HYDROCHLORIDE CRS

CAS: 175865-59-5

VALGANCICLOVIR HYDROCHLORIDE CRS

Ref: 41-Y0002359

Valganciclovir Hydrochloride

CAS: 175865-59-5

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₁₄H₂₂N₆O₅·HCl

Color and Shape: White Off-White Powder

Molecular weight: 354.16517

Ref: 45-1708004

Valganciclovir hydrochloride

CAS: 175865-59-5

Valganciclovir HCl is a prodrug of ganciclovir, an antiviral nucleoside analog; it inhibits viral DNA replication.

Formula: C₁₄H₂₃ClN₆O₅

Purity: 98.55% - 99.32%

Color and Shape: White Crystalline Solid

Molecular weight: 390.82

Ref: TM-T1533

L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)

CAS: 175865-59-5

Formula: C₁₄H₂₃ClN₆O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 390.8226

Ref: IN-DA00218L

Valganciclovir hydrochloride

CAS: 175865-59-5

Valganciclovir hydrochloride

Purity: ≥98%

Molecular weight: 390.82g/mol

Ref: 54-BUP17167

(2S)-2-((2-Amino-6-Oxo-1H-Purin-9(6H)-Yl)Methoxy)-3-Hydroxypropyl2-Amino-3-MethylbutanoateHydrochloride

CAS: 175865-59-5

(2S)-2-((2-Amino-6-Oxo-1H-Purin-9(6H)-Yl)Methoxy)-3-Hydroxypropyl2-Amino-3-MethylbutanoateHydrochloride

Purity: 98%

Molecular weight: 390.82g/mol

Ref: 54-OR1008006

Valganciclovir-d5 (Mixture of Diastereomers)

CAS: 175865-59-5, 175865-60-8

Formula: C₁₄H₁₇D₅N₆O₅

Color and Shape: White To Off-White Solid

Molecular weight: 359.40

Ref: 4Z-V-112

Valganciclovir HCl (Mixture of Diastereomers)

CAS: 175865-59-5

Formula: C₁₄H₂₂N₆O₅·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 354.37 36.46

Ref: 4Z-V-111

Valganciclovir hydrochloride hydrate

CAS: 175865-59-5

Formula: C₁₄H₂₂N₆O₅

Molecular weight: 354.36

Ref: 7W-GP9471

Valganciclovir hydrochloride

CAS: 175865-59-5

Formula: C₁₄H₂₂N₆O₅·HCl·xH₂O

Purity: (HPLC) 97.0 - 102 %

Color and Shape: White to off-white powder

Molecular weight: 390.82 (anhydrous)

Ref: 7W-GK8723

(2RS)-Valganciclovir-d8 HCl(L-valine-d8)

CAS: 1132088-63-1, 175865-59-5

Purity: 99 atom % D

Molecular weight: 398.83

Ref: 3U-D7998

Valganciclovir hydrochloride

CAS: 175865-59-5

Formula: C₁₄H₂₃ClN₆O₅

Purity: 99.0%

Color and Shape: Solid

Molecular weight: 390.83

Ref: 10-F225723

Valganciclovir Hydrochloride

CAS: 175865-59-5

Color and Shape: White To Off-White

Ref: 86-MM3267.00

Valganciclovir-d5 Hydrochloride

Controlled Product

CAS: 175865-59-5

Formula: C₁₄H₁₈D₅ClN₆O₅

Purity: >90%

Color and Shape: Neat

Molecular weight: 395.85

Ref: TR-V092002

Valganciclovir Hydrochloride

Controlled Product

CAS: 175865-59-5

Stability Hygroscopic
Applications A pro-drug of Ganciclovir. Used in treatment of retro-virus.
References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),

Formula: C₁₄H₂₂N₆O₅·ClH

Color and Shape: White To Off-White

Molecular weight: 390.82

Ref: TR-V092000

Valganciclovir hydrochloride

CAS: 175865-59-5

Valganciclovir hydrochloride is a prodrug of ganciclovir. It is an antiviral drug used for the treatment and prevention of cytomegalovirus (CMV) infections. Valganciclovir hydrochloride is a prodrug of ganciclovir, which is converted to the active form in humans by esterases in the liver. Valganciclovir hydrochloride has been shown to be effective against CMV and other herpesviruses, such as herpes zoster virus, varicella-zoster virus, and Epstein-Barr virus. It has minimal toxicity and does not cause bone marrow suppression or organ damage at low doses. Valganciclovir hydrochloride also has a matrix effect that reduces the bioavailability of other drugs taken concurrently with it.

Formula: C₁₄H₂₂N₆O₅•HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 390.82 g/mol

Ref: 3D-FV28652