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CAS 175865-60-8

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Valganciclovir

Description:
Valganciclovir is an antiviral medication primarily used in the treatment and prevention of cytomegalovirus (CMV) infections, particularly in immunocompromised patients, such as those undergoing organ transplantation. It is an ester prodrug of ganciclovir, which means it is converted into its active form after administration. Valganciclovir is characterized by its ability to inhibit viral DNA synthesis by targeting the viral DNA polymerase, thereby preventing the replication of the virus. The substance is typically administered orally and has improved bioavailability compared to ganciclovir, making it more effective in clinical settings. Valganciclovir is known for its potential side effects, which may include bone marrow suppression, leading to conditions such as neutropenia and thrombocytopenia, as well as gastrointestinal disturbances. Its chemical structure includes a guanine derivative, and it is classified under the category of nucleoside analogs. Due to its potent antiviral activity, careful monitoring is essential during treatment to manage any adverse effects and ensure therapeutic efficacy.
Formula:C14H22N6O5
InChI:InChI=1/C14H22N6O5/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22)/t8?,9-/m0/s1
InChI key:InChIKey=WPVFJKSGQUFQAP-GKAPJAKFSA-N
SMILES:C(OC(COC([C@H](C(C)C)N)=O)CO)N1C2=C(N=C1)C(=O)N=C(N)N2
Synonyms:
  • 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate
  • 5-Amino-3-[1-(hydroxymethyl)-2-(L-valyloxy)ethoxymethyl]-6,7- dihydro-3H-imidazo[4,5-d]pyrimidin-7-one
  • <span class="text-smallcaps">L</span>-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester
  • Rovalcyte
  • Valcept
  • Valgancyclovir
  • L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester
  • Valganciclovir
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Found 6 products.