CAS 176022-59-6

roxifiban

Description:

Roxifiban is a synthetic chemical compound classified as a glycoprotein IIb/IIIa receptor antagonist, primarily used in the context of cardiovascular medicine. It functions by inhibiting platelet aggregation, thereby reducing the risk of thrombus formation in patients with acute coronary syndromes. Roxifiban is characterized by its ability to selectively bind to the glycoprotein IIb/IIIa receptor on platelets, which plays a crucial role in the final common pathway of platelet activation and aggregation. The compound is typically administered intravenously and has been investigated for its efficacy in various clinical settings, including percutaneous coronary interventions. Its pharmacokinetic profile includes rapid onset of action and a relatively short half-life, necessitating careful monitoring and dosage adjustments in clinical use. As with many antiplatelet agents, potential side effects may include bleeding complications, which require careful patient selection and management. Overall, roxifiban represents a significant advancement in antithrombotic therapy, contributing to improved outcomes in patients with cardiovascular diseases.

Formula: C₂₃H₃₃N₅O₈

InChI: InChI=1/C21H29N5O6.C2H4O2/c1-3-4-9-31-21(29)25-17(20(28)30-2)12-24-18(27)11-15-10-16(26-32-15)13-5-7-14(8-6-13)19(22)23;1-2(3)4/h5-8,15,17H,3-4,9-12H2,1-2H3,(H3,22,23)(H,24,27)(H,25,29);1H3,(H,3,4)/t15-,17+;/m1./s1

Synonyms:

• DMP 754
• (2S)-3-(2-((5R)-3-(p-Amidinophenyl)-2-isoxazolin-5-yl)acetamido)-2-(carboxyamino)propionic acid, 2-butyl methyl ester, monoacetate
• Roxifiban acetate
• L-Alanine, 3-((((5R)-3-(4-(aminoiminomethyl)phenyl)-4,5-dihydro-5-isoxazolyl)acetyl)amino)-N-(butoxycarbonyl)-, methyl ester, monoacetate
• methyl N-(butoxycarbonyl)-3-({[(5R)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetyl}amino)-L-alaninate acetate (1:1)
• L-Alanine, 3-(((3-(4-(aminoiminomethyl)phenyl)-4,5-dihydro-5-isoxazolyl)acetyl)amino)-N-(butoxycarbonyl)-, methyl ester, (R)-, monoacetate

Roxifiban acetate

CAS: 176022-59-6

Roxifiban acetate

Purity: ≥95%

Molecular weight: 507.54g/mol

Ref: 54-BUP06817

Roxifiban acetate

CAS: 176022-59-6

Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in

Formula: C₂₃H₃₃N₅O₈

Purity: 97.91% - 98.36%

Color and Shape: Solid

Molecular weight: 507.54

Ref: TM-T24733