The amide anion, represented by the chemical formula NH2^-, is a negatively charged species derived from ammonia (NH3) by the removal of a hydrogen ion (H+). It is characterized by its strong basicity and nucleophilicity, making it a potent reagent in organic synthesis. The amide anion is typically encountered in the form of its salts, such as sodium amide (NaNH2), which is commonly used in various chemical reactions, including deprotonation and as a strong base in the formation of carbon-carbon bonds. The amide anion is highly reactive and can participate in a range of reactions, including nucleophilic substitutions and eliminations. It is also known for its role in the synthesis of amines and other nitrogen-containing compounds. However, due to its reactivity, it must be handled with care, as it can react violently with water and other protic solvents, releasing ammonia gas. Overall, the amide anion is a valuable intermediate in synthetic organic chemistry, particularly in the preparation of complex molecules.

Amide anion

17655-31-1: The amide anion, represented by the chemical formula NH2^-, is a negatively charged species derived from ammonia (NH3) by the removal of a hydrogen ion (H+). It is characterized by its strong basicity and nucleophilicity, making it a potent reagent in organic synthesis. The amide anion is typically encountered in the form of its salts, such as sodium amide (NaNH2), which is commonly used in various chemical reactions, including deprotonation and as a strong base in the formation of carbon-carbon bonds. The amide anion is highly reactive and can participate in a range of reactions, including nucleophilic substitutions and eliminations. It is also known for its role in the synthesis of amines and other nitrogen-containing compounds. However, due to its reactivity, it must be handled with care, as it can react violently with water and other protic solvents, releasing ammonia gas. Overall, the amide anion is a valuable intermediate in synthetic organic chemistry, particularly in the preparation of complex molecules.

CAS 17655-31-1

Amide anion

Amide

Ref: IN-DA0024R7