CAS 176591-49-4

urocortin

Description:

Urocortin is a neuropeptide that belongs to the corticotropin-releasing factor (CRF) family, primarily involved in the stress response and regulation of various physiological processes. It is characterized by its role in modulating the hypothalamic-pituitary-adrenal (HPA) axis, influencing stress-related behaviors, and promoting anxiolytic effects. Urocortin is known to bind to CRF receptors, particularly CRF receptor type 2, which mediates its effects on cardiovascular, metabolic, and neuroendocrine functions. This peptide is also implicated in the regulation of appetite and energy balance, as well as having potential roles in neuroprotection and the modulation of pain. Structurally, urocortin is a peptide composed of a specific sequence of amino acids, which contributes to its biological activity. Its therapeutic potential is being explored in various conditions, including anxiety disorders and depression, due to its ability to influence mood and stress responses. Overall, urocortin represents a significant area of interest in neurobiology and pharmacology.

Formula: C₂₀₄H₃₃₇N₆₃O₆₄

Synonyms:

• Urocortin (human)
• H-Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Urocortin (human)

CAS: 176591-49-4

Formula: C₂₀₄H₃₃₇N₆₃O₆₄

Purity: 85%

Color and Shape: Solid

Molecular weight: 4696.2423

Ref: IN-DA00AP9A

Urocortin, human

CAS: 176591-49-4

Urocortin, human (Human urocortin I) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF).

Formula: C₂₀₄H₃₃₇N₆₃O₆₄

Purity: 99.26%

Color and Shape: Solid

Molecular weight: 4696.32

Ref: TM-TP1021

Urocortin (human) trifluoroacetate salt

CAS: 176591-49-4

Trifluoroacetate salt

Formula: C₂₀₄H₃₃₇N₆₃O₆₄

Purity: Min. 95%

Molecular weight: 4,696.24 g/mol

Ref: 3D-FU109073

Urocortin (human)

CAS: 176591-49-4

Using a genomic library, human urocortin (UCN) has been cloned and localized to human chromosome 2. Human and rat urocortin share 95% identity within the mature peptide region. Human urocortin binds with high affinity to CRF receptor types 1, 2α, and 2β, stimulates cAMP accumulation from cells transfected with these receptors and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.

Formula: C₂₀₄H₃₃₇N₆₃O₆₄

Purity: 95.7%

Color and Shape: White Powder

Molecular weight: 4696.31

Ref: 01-4027201

Urocortin (Human)

CAS: 176591-49-4

Urocortin is a peptide hormone that belongs to the corticotropin-releasing factor (CRF) family. It stimulates the release of adrenocorticotropic hormone (ACTH) and other hormones from the anterior pituitary gland. Urocortin has been shown to bind to three different types of ion channels: voltage-gated calcium channels, potassium channels, and chloride channels. The purified peptide is a colorless or white crystalline powder with a molecular weight of 542.6 Daltons. The antibody against urocortin is used in pharmacological research as an activator or inhibitor of protein interactions.

Formula: C₂₀₄H₃₃₇N₆₃O₆₄

Purity: Min. 95%

Molecular weight: 4,696.2 g/mol

Ref: 3D-PUC-4328-S