CAS 17670-19-8

6-thioguanosine 5'-triphosphate

Description:

6-Thioguanosine 5'-triphosphate (6-thio-GTP) is a nucleotide analog of guanosine triphosphate (GTP), characterized by the presence of a sulfur atom at the 6-position of the guanine base. This modification imparts unique biochemical properties, making it a valuable tool in molecular biology and biochemistry. 6-thio-GTP can participate in various enzymatic reactions, often serving as a substrate for RNA polymerases and other enzymes that utilize GTP. Its structural similarity to GTP allows it to mimic the natural nucleotide, facilitating studies on RNA synthesis and protein translation. Additionally, the sulfur atom can influence the stability and reactivity of the molecule, potentially affecting its interactions with proteins and nucleic acids. 6-thioguanosine 5'-triphosphate is often used in research to investigate cellular processes, signaling pathways, and the mechanisms of nucleotide metabolism. Its CAS number, 17670-19-8, is a unique identifier that aids in the cataloging and retrieval of information related to this compound in chemical databases.

Formula: C₁₀H₁₆N₅O₁₃P₃S

InChI: InChI=1/C10H16N5O13P3S/c11-10-13-7-4(8(32)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-3,5-6,9,16-17H,1H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,32)/t3-,5-,6-,9+/m1/s1

Synonyms:

• 2-Amino-6-mercapto-9-ribofuranosylpurine 5'-triphosphate
• 6-Mercapto-GTP
• 9beta-D-Ribofuranosyl-2-amino-6-mercaptopurine 5'-triphosphate
• S6-Gtp
• Thiogtp
• Guanosine 5'-(tetrahydrogen triphosphate), 6-thio-
• 2-amino-9-[5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-alpha-D-ribofuranosyl]-3,9-dihydro-6H-purine-6-thione
• 6-Thioguanosine 5'-triphosphate
• 6-Thioguanosine Triphosphate
• 6-Thio-GTP
• 6-Thioguanosine-5'-O-triphosphate sodium salt - 10mM aqueous solution
• 6-Thioguanosine-5-O-triphosphate

6-thioguanosine 5'-triphosphate

CAS: 17670-19-8

Formula: C₁₆H₃₁N₆O₁₃P₃S

Color and Shape: Solid

Molecular weight: 640.4360

Ref: IN-DA00B62Z

6-Thioguanosine-5'-O-triphosphate sodium - 10mM aqueous solution

CAS: 17670-19-8

6-Thioguanosine-5'-O-triphosphate sodium salt is a nucleotide analog that inhibits the synthesis of RNA, DNA and protein. It binds to the guanine nucleotide-binding site on the enzyme RNA polymerase and blocks transcription. This leads to a decreased amount of mRNA, thereby slowing or stopping protein production. 6TGTP also has been shown to be effective in treating cancer as it inhibits enzymes involved in cellular metabolism and induces cell death. 6TGTP has been shown to have no effect on mammalian cells when incubated with 10 mM magnesium ion.

Formula: C₁₀H₁₆N₅O₁₃P₃S•Nax

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 539.25 g/mol

Ref: 3D-NT36523

6-Thioguanosine Triphosphate Triethylamine Salt (>90%)

Controlled Product

CAS: 17670-19-8

Formula: C₁₀H₁₆N₅O₁₃P₃S·xC₆H₁₅N

Purity: >90%

Color and Shape: Neat

Molecular weight: 539.25 + x(101.19)

Ref: TR-T350785

6-Thioguanosine Triphosphate-13C,15N2 Triethylamine Salt

Controlled Product

CAS: 17670-19-8

Formula: C₉CH₁₆N₃N₂O₁₃P₃S•xC₆H₁₅N

Color and Shape: Neat

Molecular weight: 542.23 + x(101.19)

Ref: TR-T350787