CAS 176785-25-4

1-30-Pituitary adenylate cyclase-activating peptide-38 (human), 15-L-arginine-17-L-leucine-20-L-arginine-21-L-arginine-30-L-argininamide- (9CI)

Description:

1-30-Pituitary adenylate cyclase-activating peptide-38 (human), commonly referred to as PACAP-38, is a neuropeptide that plays a crucial role in various physiological processes, including neuroprotection, neurotransmission, and regulation of circadian rhythms. This peptide consists of 38 amino acids and is characterized by its ability to activate adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in target cells. The specific sequence of amino acids, including multiple arginine and leucine residues, contributes to its biological activity and receptor binding affinity. PACAP-38 is involved in the modulation of stress responses, immune function, and the regulation of hormone secretion. Its diverse functions are mediated through its interaction with specific receptors, primarily PACAP receptor 1 (PAC1), which is widely distributed in the central nervous system and peripheral tissues. The CAS number 176785-25-4 uniquely identifies this peptide, facilitating its recognition in scientific literature and databases. Overall, PACAP-38 is a significant molecule in neurobiology and endocrinology, with potential implications in therapeutic applications for various disorders.

Formula: C₁₅₇H₂₅₃N₅₃O₄₂

Synonyms:

• 1-30-Pituitary adenylate cyclase-activating peptide-38 (human), 15-L-arginine-17-L-leucine-20-L-arginine-21-L-arginine-30-L-argininamide-
• 1-30-Pituitary adenylate cyclase-activating peptide-38 (human), 15-L-arginine-17-L-leucine-20-L-arginine-21-L-arginine-30-L-argininamide- (9CI)

[Arg-15,20,21,Leu17]-PACAP-Gly-Lys-Arg-NH2

CAS: 176785-25-4

[Arg-15,-20,-21, Leu17]-PACAP-Gly-Lys-Arg-NH2 (BM-PACAP) is a synthetic analogue of PACAP 1-27 that exhibits a relaxant effect [1].

Formula: C₁₅₇H₂₅₃N₅₃O₄₂

Color and Shape: Solid

Molecular weight: 3555.02

Ref: TM-T83510