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CAS 176976-42-4

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4-Chloro-3-(trifluoromethyl)benzeneboronic acid

Description:
4-Chloro-3-(trifluoromethyl)benzeneboronic acid is an organoboron compound characterized by the presence of a boronic acid functional group attached to a chlorinated aromatic ring. This compound features a trifluoromethyl group, which significantly influences its electronic properties and reactivity. The boronic acid moiety allows for participation in various chemical reactions, particularly in Suzuki coupling reactions, making it valuable in organic synthesis and medicinal chemistry. The presence of the chlorine and trifluoromethyl groups enhances its lipophilicity and can affect its biological activity. Typically, this compound is a solid at room temperature and is soluble in polar organic solvents. Its unique structure makes it a useful intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, the trifluoromethyl group can impart unique properties such as increased metabolic stability and altered pharmacokinetics in drug development. Safety data should be consulted for handling, as boronic acids can be reactive and may pose health risks if not managed properly.
Formula:C7H5BClF3O2
InChI:InChI=1/C3H6F3N.ClH/c1-2(7)3(4,5)6;/h2H,7H2,1H3;1H
SMILES:CC(C(F)(F)F)N.Cl
Synonyms:
  • 4-Chloro-3-(trifluoromethyl)phenylboronic acid
  • 1,1,1-Trifluoropropan-2-Amine Hydrochloride (1:1)
  • 4-Chloro-3-(Trifluoromethyl)Phenyl Boronic Acid
  • AKOS BRN-0227
  • 4-Chloro-3-(Trifluoromethyl)Ph
  • 4-CHLORO-3-(TRIFLUOROMETYHL)PHENYLBORONIC ACID
  • 4-CHLORO-3-(TRIFLUOROMETHYL)BENZENEBORONIC ACID
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