CAS 177036-78-1

(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester

Description:

(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester, with CAS number 177036-78-1, is a chiral compound characterized by its specific stereochemistry, which is indicated by the (S) designation. This compound features a propionic acid backbone with a hydroxyl group and a methoxy group, along with two phenyl groups attached to the central carbon, contributing to its diphenyl structure. The presence of these functional groups suggests that it may exhibit interesting chemical reactivity and potential biological activity. As a methyl ester, it is likely to be more lipophilic, which can influence its solubility and permeability in biological systems. The compound's chirality may also play a significant role in its pharmacological properties, as different enantiomers can exhibit different biological effects. Overall, (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester is of interest in fields such as medicinal chemistry and drug development, where the understanding of stereochemistry is crucial for the design of effective therapeutic agents.

Formula: C₁₇H₁₈O₄

Synonyms:

• Methyl (2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoate
• (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester
• (S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid Methyl Ester (Ambrisentan)

Benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-, methyl ester, (αS)-

CAS: 177036-78-1

Formula: C₁₇H₁₈O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 286.3224

Ref: IN-DA00252S

Ambrisentan Impurity 10

CAS: 177036-78-1

Formula: C₁₇H₁₈O₄

Molecular weight: 286.33

Ref: 4Z-A-3111

(S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester

Controlled Product

CAS: 177036-78-1

Impurity Ambrisentan Hydroxyester Impurity
Applications (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester is an impurity in the synthesis of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive. (Ambrisentan Hydroxyester Impurity)
References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),

Formula: C₁₇H₁₈O₄

Color and Shape: Neat

Molecular weight: 286.32

Ref: TR-H946295

Ambrisentan Hydroxyester Impurity

CAS: 177036-78-1

Formula: C₁₇H₁₈O₄

Molecular weight: 286.32

Ref: ST-EA-CP-A15004