CAS 177036-94-1

Ambrisentan

Description:

Ambrisentan is a selective endothelin receptor antagonist primarily used in the treatment of pulmonary arterial hypertension (PAH). It works by blocking the action of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure in the pulmonary arteries. The chemical formula of ambrisentan is C23H26N2O5S, and it features a sulfonamide group, which contributes to its pharmacological activity. Ambrisentan is characterized by its high oral bioavailability and a relatively long half-life, allowing for once-daily dosing. It is typically administered in tablet form and is known to have a favorable safety profile, although it may cause side effects such as headache, flushing, and potential liver enzyme elevations. Due to its mechanism of action, ambrisentan is effective in improving exercise capacity and overall quality of life for patients with PAH. Regular monitoring is recommended for patients on this medication to assess liver function and ensure safety during treatment.

Formula: C₂₂H₂₂N₂O₄

InChI: InChI=1/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

InChI key: InChIKey=OUJTZYPIHDYQMC-LJQANCHMSA-N

SMILES: C([C@H](OC=1N=C(C)C=C(C)N1)C(O)=O)(OC)(C2=CC=CC=C2)C3=CC=CC=C3

Synonyms:

• (2S)-2-[(4,6-Dimethylpyrimidin-2-Yl)Oxy]-3-Methoxy-3,3-Diphenylpropanoic Acid
• (As)-A-[(4,6-Dimethyl-2-Pyrimidinyl)Oxy]--Methoxy--Phenylbenzenepropanoic Acid
• (αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid
• 2-(4,6-Dimethylpyrimidin-2-Yl)Oxy-3-Methoxy-3,3-Di(Phenyl)Propanoic Acid
• Benzenepropanoic acid, α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (S)-
• Benzenepropanoic acid, α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)-
• Bsf 208075
• Bsf 208075,(+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-Yl)Oxy]-3-Methoxy-3,3-Diphenylpropanoic Acid
• Letairis
• Lu 208075
• Volibris
• Ambrisentan
• (S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic Acid
• Anrisentan API
• Ambrisentan, >=98%
• ((S)-Ambrisentan)
• (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid,bsf-208075
• (R,S)-AMbrisentan-d5
• Benzenepropanoic acid, alpha-[(4,6-diMethyl-2-pyriMidinyl)oxy]-beta-Methoxy-beta-phenyl-, (alphaS)-
• Ambrisentan Tablets
• Ambrisentan USP/EP/BP
• ambrisentan,CID 6918493
• LU-208075,BSF-208075
• Ambrisentan,2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid
• AMbrisentan (BSF 208075)
• CS-135

Ambrisentan

CAS: 177036-94-1

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₂H₂₂N₂O₄

Color and Shape: White Light Yellow Crystalline Powder

Molecular weight: 378.15796

Ref: 45-1019111

(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid

CAS: 177036-94-1

Formula: C₂₂H₂₂N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 378.4211

Ref: IN-DA00252R

Ambrisentan

CAS: 177036-94-1

Ambrisentan

Purity: ≥98%

Molecular weight: 378.42g/mol

Ref: 54-BUP13149

Ambrisentan,2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid

CAS: 177036-94-1

Ambrisentan,2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid

Purity: 98%

Molecular weight: 378.42g/mol

Ref: 54-OR1012277

Ambrisentan

CAS: 177036-94-1

Formula: C₂₂H₂₂N₂O₄

Molecular weight: 378.42

Ref: 7W-GP0492

Ambrisentan

CAS: 177036-94-1

Formula: C₂₂H₂₂N₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 378.43

Ref: 4Z-A-311

Ambrisentan

CAS: 177036-94-1

Color and Shape: Neat

Ref: 86-MM3756.00

Ambrisentan

CAS: 177036-94-1

Formula: C₂₂H₂₂N₂O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 378.43

Ref: 3B-A2966

Ambrisentan

CAS: 177036-94-1

Ambrisentan, an endothelin antagonist for PAH, has a low risk of liver enzyme elevation, not linked to acute liver injury.

Formula: C₂₂H₂₂N₂O₄

Purity: 99.65% - 99.86%

Color and Shape: Solid

Molecular weight: 378.42

Ref: TM-T1655

Ambrisentan

Controlled Product

CAS: 177036-94-1

Applications Nonpeptide endothelin ETA receptor antagonist. Antihypertensive.
References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),

Formula: C₂₂H₂₂N₂O₄

Color and Shape: Off-White

Molecular weight: 378.42

Ref: TR-A575860

Ambrisentan

CAS: 177036-94-1

Endothelin A receptor antagonist; anti-hypertensive

Formula: C₂₂H₂₂N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 378.42 g/mol

Ref: 3D-FA17344

Ambrisentan - Bio-X ™

CAS: 177036-94-1

Ambrisentan is a type A endothelin receptor antagonist that is used for the treatment of pulmonary arterial hypertension. This drug selectively targets the endothelin type A receptor and inhibits its action by preventing vasoconstriction as the endothelin type A receptor promotes vasoconstriction and cell proliferation.

Formula: C₂₂H₂₂N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 378.42 g/mol

Ref: 3D-BA164153