CAS 177036-94-1: Ambrisentan
Description:Ambrisentan is a selective endothelin receptor antagonist primarily used in the treatment of pulmonary arterial hypertension (PAH). It works by blocking the action of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure in the pulmonary arteries. The chemical formula of ambrisentan is C23H26N2O5S, and it features a sulfonamide group, which contributes to its pharmacological activity. Ambrisentan is characterized by its high oral bioavailability and a relatively long half-life, allowing for once-daily dosing. It is typically administered in tablet form and is known to have a favorable safety profile, although it may cause side effects such as headache, flushing, and potential liver enzyme elevations. Due to its mechanism of action, ambrisentan is effective in improving exercise capacity and overall quality of life for patients with PAH. Regular monitoring is recommended for patients on this medication to assess liver function and ensure safety during treatment.
Formula:C22H22N2O4
InChI:InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChI key:InChIKey=OUJTZYPIHDYQMC-LJQANCHMSA-N
SMILES:O=C(O)C(OC=1N=C(C=C(N1)C)C)C(OC)(C=2C=CC=CC2)C=3C=CC=CC3
- Synonyms:
- (2S)-2-[(4,6-Dimethylpyrimidin-2-Yl)Oxy]-3-Methoxy-3,3-Diphenylpropanoic Acid
- (As)-A-[(4,6-Dimethyl-2-Pyrimidinyl)Oxy]--Methoxy--Phenylbenzenepropanoic Acid
- (αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid
- 2-(4,6-Dimethylpyrimidin-2-Yl)Oxy-3-Methoxy-3,3-Di(Phenyl)Propanoic Acid
- Benzenepropanoic acid, α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (S)-
- Benzenepropanoic acid, α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)-
- Bsf 208075
- Bsf 208075,(+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-Yl)Oxy]-3-Methoxy-3,3-Diphenylpropanoic Acid
- Letairis
- Lu 208075
- See more synonyms
- Volibris
- Ambrisentan
![Benzenepropanoic acid, α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)-](https://static.cymitquimica.com/products/IN/thumb/DA00252R.jpg)
