CAS 177469-96-4

2(S)-Cyclopentyl-2-[4-(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-ylmethyl)phenyl]-N-[2-hydroxy-1(R)-phenylethyl]acetamide

Description:

2(S)-Cyclopentyl-2-[4-(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-ylmethyl)phenyl]-N-[2-hydroxy-1(R)-phenylethyl]acetamide, with CAS number 177469-96-4, is a complex organic compound characterized by its multi-ring structure and various functional groups. This substance features a cyclopentyl group, which contributes to its hydrophobic characteristics, and a pyridoindole moiety that may impart biological activity. The presence of an acetamide functional group suggests potential interactions with biological targets, possibly influencing its pharmacological properties. The compound also contains a hydroxyphenyl group, which can enhance solubility and reactivity. Its intricate structure indicates potential applications in medicinal chemistry, particularly in the development of therapeutic agents. The stereochemistry, denoted by the (S) and (R) designations, implies specific spatial arrangements that can significantly affect the compound's biological activity and interactions. Overall, this compound exemplifies the complexity often found in drug design, where multiple functional groups and stereochemistry play crucial roles in determining efficacy and safety profiles.

Formula: C₃₅H₃₇N₃O₂

InChI: InChI=1/C35H37N3O2/c1-23-19-24(2)36-34-32(23)29-17-8-9-18-31(29)38(34)21-25-11-10-16-28(20-25)33(27-14-6-7-15-27)35(40)37-30(22-39)26-12-4-3-5-13-26/h3-5,8-13,16-20,27,30,33,39H,6-7,14-15,21-22H2,1-2H3,(H,37,40)/t30-,33-/m0/s1

InChI key: InChIKey=KIMRCJZMVARVSU-DITALETJSA-N

SMILES: C(N1C=2C(C=3C1=CC=CC3)=C(C)C=C(C)N2)C4=CC=C([C@@H](C(N[C@@H](CO)C5=CC=CC=C5)=O)[C@H]6CCCC6)C=C4

Synonyms:

• (2S)-2-cyclopentyl-2-{3-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]phenyl}-N-[(1R)-2-hydroxy-1-phenylethyl]ethanamide
• (αS)-α-Cyclopentyl-4-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]-N-[(1R)-2-hydroxy-1-phenylethyl]benzeneacetamide
• Bay-13-9952
• Benzeneacetamide, α-cyclopentyl-4-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]-N-(2-hydroxy-1-phenylethyl)-, [R-(R*,S*)]-
• Benzeneacetamide, α-cyclopentyl-4-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]-N-[(1R)-2-hydroxy-1-phenylethyl]-, (αS)-
• Implitapide
• (2S)-2-cyclopentyl-2-[3-[(2,4-dimethylpyrido[2,3-b]indol-9-yl)methyl]phenyl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide
• Unii-Q70OH404hr
• 2(S)-Cyclopentyl-2-[4-(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-ylmethyl)phenyl]-N-[2-hydroxy-1(R)-phenylethyl]acetamide
• (alphaS)-alpha-Cyclopentyl-4-[(2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl]-N-[(1R)-2-hydroxy-1-phenylethyl]benzeneacetamide
• AEGR 427

Implitapide

Controlled Product

CAS: 177469-96-4

Formula: C₃₅H₃₇N₃O₂

Color and Shape: Neat

Molecular weight: 531.687

Ref: TR-I415005

Implitapide

CAS: 177469-96-4

Implitapide is a drug that belongs to the group of statins. It is a prodrug that undergoes hydrolysis by hepatic lipase and soluble guanylate cyclase to form dodecanedioic acid and 2-hydroxy-4,5-dihydro-3(2H)-furanone. Implitapide inhibits cholesterol synthesis by inhibiting hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and reduces the size of atherosclerotic lesions in animal models. Clinical studies have shown that implitapide has been effective in reducing serum triglycerides, LDL cholesterol, apolipoprotein B, total cholesterol, and low density lipoprotein cholesterol as well as increasing HDL cholesterol levels. Implitapide may also inhibit protein synthesis by binding to the enzyme cholesteryl ester transfer protein. This interaction prevents the transfer of cholesteryl esters from HDL to other lipoprote

Formula: C₃₅H₃₇N₃O₂

Purity: Min. 95%

Molecular weight: 531.7 g/mol

Ref: 3D-CHA46996

Implitapide

CAS: 177469-96-4

Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

Formula: C₃₅H₃₇N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 531.69

Ref: TM-T15570