CAS 17780-72-2

Clorgyline

Description:

Clorgyline is a selective irreversible inhibitor of monoamine oxidase A (MAO-A), primarily used in research and clinical settings to study the role of monoamines in various physiological and pathological processes. It is characterized by its ability to inhibit the breakdown of neurotransmitters such as serotonin, norepinephrine, and dopamine, thereby increasing their levels in the brain. Clorgyline is typically presented as a white to off-white crystalline powder and is soluble in organic solvents. Its mechanism of action involves the covalent modification of the MAO-A enzyme, leading to prolonged effects on neurotransmitter metabolism. Due to its specificity for MAO-A, clorgyline is often utilized in studies related to mood disorders, anxiety, and other neuropsychiatric conditions. However, its irreversible nature necessitates careful consideration regarding dosage and potential side effects, particularly in relation to dietary restrictions associated with tyramine. Overall, clorgyline serves as a valuable tool in neuropharmacology and the exploration of monoamine-related pathways.

Formula: C₁₃H₁₅Cl₂NO

InChI: InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3

InChI key: InChIKey=BTFHLQRNAMSNLC-UHFFFAOYSA-N

SMILES: O(CCCN(CC#C)C)C1=C(Cl)C=C(Cl)C=C1

Synonyms:

• 17780-72-2
• 2-Propynylamine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-
• 2-propyn-1-amine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-
• Clorgyline
• M & B 9302
• M and B 9302
• N-(3-(2,4-Dichlorophenoxy)propyl)-N-methyl-2-propyn-1-amine
• N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)Propylamine
• N-[3-(2,4-Dichlorophenoxy)Propyl]-N-Methyl-N-Prop-2-Ynylamine
• N-[3-(2,4-Dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine
• [3-(2,4-Dichlorophenoxy)propyl](methyl)(2-propynyl)amine
• n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-amin
• N-Methyl-N-[3-(2,4-dichlorophenoxy)propyl]-2-propyne-1-amine
• clorgiline
• n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylamin
• m&b9302
• mandb9302

Clorgyline

CAS: 17780-72-2

Clorgyline

Purity: ≥98%

Molecular weight: 272.17g/mol

Ref: 54-BUP20935

Clorgyline

CAS: 17780-72-2

Clorgyline,M&B 9302, an irreversible and selective MAO-A inhibitor with the advantages of oral activity and blood-brain barrier permeability, antidepressant.

Formula: C₁₃H₁₅Cl₂NO

Purity: 98.39%

Color and Shape: Solid

Molecular weight: 272.17

Ref: TM-T70206